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经右腋下小切口对法洛四联症患儿进行预后分析。

Prognostic analysis of children with tetralogy of Fallot through a small incision in the right axilla.

作者信息

Meng Fanwei, Li Jianchao, Liang Weijie, Dong Haoju, Li Bing

机构信息

Fuwai Central China Cardiovascular Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.

出版信息

Front Cardiovasc Med. 2025 Jun 30;12:1457554. doi: 10.3389/fcvm.2025.1457554. eCollection 2025.

Abstract

OBJECTIVE

Compare the clinical efficacy of a minimally invasive small incision in the right axilla vs. traditional median sternotomy in the surgical treatment of tetralogy of Fallot (TOF).

METHODS

A retrospective analysis was conducted on 330 infants and young children under the age of 3 who underwent radical surgery for tetralogy of Fallot between March 2022 and March 2024. Patients were categorized into two groups based on the surgical approach. To ensure the consistency of preoperative baseline data (weight, gender, age, O saturation, main pulmonary artery and pulmonary branches diameter, McGoon ratio) between the two groups, the propensity score matching method was applied for 1:1 matching, resulting in two cohorts of 228 cases. The minimally invasive group ( = 114) received surgery through a small incision in the right axilla, while the median sternotomy group ( = 114) underwent surgery via median sternotomy. Clinical parameters including demographic data (weight, gender, age, O saturation, main pulmonary artery and pulmonary branches diameter, McGoon ratio), cardiopulmonary bypass metrics (duration of bypass, aortic cross-clamp time), duration of mechanical ventilation, intensive care unit (ICU) stay, postoperative chest drainage volume within 24 h, pulmonary valve regurgitation, and complications (reintubation, peritoneal dialysis, reoperation, extracorporeal membrane oxygenation (ECMO) use, infection, and mortality) were collected for comparison between groups.

RESULTS

No statistically significant differences were observed between the two groups in 24 h chest drainage volume, mortality, reintubation, reoperation, ECMO use, and infection. However, the minimally invasive group showed significantly shorter ventilator duration and ICU stay and a reduced rate of peritoneal dialysis (all  < 0.05).

CONCLUSION

In infants and children under 3 years old with TOF, surgical correction via a right axillary small incision achieves equivalent clinical outcomes to traditional median sternotomy, without increasing postoperative mortality or complication rates. In addition, the minimally invasive approach offers benefits of reduced surgical trauma and enhanced postoperative recovery.

摘要

目的

比较右腋下微创小切口与传统正中胸骨切开术在法洛四联症(TOF)手术治疗中的临床疗效。

方法

对2022年3月至2024年3月期间接受法洛四联症根治手术的330例3岁以下婴幼儿进行回顾性分析。根据手术方式将患者分为两组。为确保两组术前基线数据(体重、性别、年龄、血氧饱和度、主肺动脉及肺分支直径、麦高恩比率)的一致性,采用倾向得分匹配法进行1:1匹配,得到两组各228例的队列。微创组(n = 114)通过右腋下小切口进行手术,而正中胸骨切开术组(n = 114)通过正中胸骨切开术进行手术。收集临床参数,包括人口统计学数据(体重、性别、年龄、血氧饱和度、主肺动脉及肺分支直径、麦高恩比率)、体外循环指标(体外循环持续时间、主动脉阻断时间)、机械通气时间、重症监护病房(ICU)住院时间、术后24小时胸腔引流量、肺动脉瓣反流及并发症(再次插管、腹膜透析、再次手术、体外膜肺氧合(ECMO)使用、感染及死亡率),进行组间比较。

结果

两组在24小时胸腔引流量、死亡率、再次插管、再次手术、ECMO使用及感染方面无统计学显著差异。然而,微创组的呼吸机使用时间和ICU住院时间明显缩短,腹膜透析率降低(均P < 0.05)。

结论

对于3岁以下法洛四联症婴幼儿,经右腋下小切口进行手术矫正与传统正中胸骨切开术的临床效果相当,且不增加术后死亡率或并发症发生率。此外,微创方法具有减少手术创伤和促进术后恢复的优点。

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