Marincek B, Friedburg H
Invest Radiol. 1985 Oct;20(7):701-7. doi: 10.1097/00004424-198510000-00009.
T1 and T2 proton relaxation times in six rabbit thigh V2 carcinomas were obtained from regions of interest on calculated MR images at 2.35 tesla before and after steroid administration. Mean T1 and T2 values of viable tumor tissue decreased after steroid administration, consistent with decreased tissue water content. After steroid withdrawal, T1 and T2 values returned toward baseline. Relaxation times of peritumoral muscle tissue and normal contralateral thigh muscle essentially remained unchanged. In a separate experiment, six rabbit thigh V2 carcinomas were monitored before and after steroids by 31P spectroscopy using a surface coil. No substantial steroid-related changes were recognizable. A fall of the ratio of phosphocreatine to inorganic phosphate and a signal increase from phosphomonoester and phosphodiester compounds were observed during various stages of tumor growth. Analysis of 31P spectra changes and sequential measurements of relaxation times may prove valuable for assessment of tumor growth and therapeutic response in diagnostic oncology.
在2.35特斯拉的磁场下，对6只兔大腿V2癌在给予类固醇前后获取计算磁共振图像上感兴趣区域的T1和T2质子弛豫时间。给予类固醇后，存活肿瘤组织的平均T1和T2值下降，这与组织含水量降低一致。停用类固醇后，T1和T2值恢复至基线水平。肿瘤周围肌肉组织和对侧正常大腿肌肉的弛豫时间基本保持不变。在另一项实验中，使用表面线圈通过31P波谱对6只兔大腿V2癌在给予类固醇前后进行监测。未发现与类固醇相关的实质性变化。在肿瘤生长的各个阶段观察到磷酸肌酸与无机磷酸盐的比率下降以及磷酸单酯和磷酸二酯化合物的信号增加。分析31P波谱变化和连续测量弛豫时间可能对诊断肿瘤学中评估肿瘤生长和治疗反应具有重要价值。
