Marincek B, Young S W, Muller H H, Enzmann D R
J Comput Assist Tomogr. 1981 Aug;5(4):491-5. doi: 10.1097/00004728-198108000-00005.
Computed tomographic attenuation coefficients in six rabbit thigh V2 carcinomas were studied before and after steroid treatment. In four V2 tumors with effective steroid treatment, the density difference between V2 carcinoma and normal muscles decreased on both pre- and postcontrast scans (17.9 and 21.8 Hounsfield units, respectively--HU: 1,000 scale) attributable mainly to altered tumor X-ray absorption; 3 weeks after steroid withdrawal, normal and malignant tissue density differences increased and returned toward base line. Two V2 tumors failed to respond to steroids; the precontrast density difference between V2 carcinoma and normal muscle was nearly constant, and the postcontrast density difference increased by 6.8 HU. In patients taking steroids, malignant tumors may become isodense with the surrounding normal tissue and be difficult or impossible to detect. Changes in tumor density may also prove to be a useful marker off therapeutic efficacy.
对六只兔大腿V2癌在类固醇治疗前后的计算机断层扫描衰减系数进行了研究。在四只接受有效类固醇治疗的V2肿瘤中，V2癌与正常肌肉之间的密度差异在增强扫描前和增强扫描后均降低（分别为17.9和21.8亨氏单位——HU：1000刻度），这主要归因于肿瘤X线吸收的改变；在停用类固醇3周后，正常组织与恶性组织的密度差异增加并恢复至基线水平。两只V2肿瘤对类固醇无反应；V2癌与正常肌肉之间的平扫密度差异几乎恒定，增强扫描后的密度差异增加了6.8 HU。在服用类固醇的患者中，恶性肿瘤可能与周围正常组织等密度，难以或无法检测到。肿瘤密度的变化也可能被证明是治疗效果的有用标志物。
