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误差污染泊松回归模型的迁移学习

Transfer Learning for Error-Contaminated Poisson Regression Models.

作者信息

Wu Jou-Chin, Chen Li-Pang

机构信息

Department of Statistics, National Chengchi University, Taipei, Taiwan, ROC.

出版信息

Stat Med. 2025 Jul;44(15-17):e70163. doi: 10.1002/sim.70163.

DOI:10.1002/sim.70163
PMID:40662525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333914/
Abstract

Poisson regression model has been a popular approach to characterize the count response and the covariates. With the rapid development of data collections, the additional source information can be easily recorded. To efficiently use the source data to improve the estimation under the original data, the transfer learning method is considered a strategy. However, challenging issues from the given datasets include measurement error and high-dimensionality in variables, which are not well explored in the context of transfer learning. In this paper, we propose a novel strategy to handle error-prone count responses and estimate the parameters in measurement error models by using the source data, and then employ the transfer learning method to derive the corrected estimator. Moreover, to improve the prediction and avoid the model uncertainty, we further establish the model averaging strategy. Simulation and breast cancer data studies verify the satisfactory performance of the proposed method and the validity of handling measurement error.

摘要

泊松回归模型一直是刻画计数响应和协变量的常用方法。随着数据收集的快速发展,额外的源信息可以很容易地被记录下来。为了有效地利用源数据来改进原始数据下的估计,迁移学习方法被视为一种策略。然而,给定数据集中存在的挑战性问题包括测量误差和变量的高维性,这些在迁移学习的背景下尚未得到充分探索。在本文中,我们提出了一种新颖的策略来处理容易出错的计数响应,并通过使用源数据估计测量误差模型中的参数,然后采用迁移学习方法来推导校正估计量。此外,为了提高预测并避免模型不确定性,我们进一步建立了模型平均策略。模拟和乳腺癌数据研究验证了所提方法的令人满意的性能以及处理测量误差的有效性。

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Transfer Learning for Error-Contaminated Poisson Regression Models.误差污染泊松回归模型的迁移学习
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本文引用的文献

1
Transfer Learning under High-dimensional Generalized Linear Models.高维广义线性模型下的迁移学习
J Am Stat Assoc. 2023;118(544):2684-2697. doi: 10.1080/01621459.2022.2071278. Epub 2022 Jun 27.
2
On high-dimensional Poisson models with measurement error: Hypothesis testing for nonlinear nonconvex optimization.关于具有测量误差的高维泊松模型:非线性非凸优化的假设检验
Ann Stat. 2023 Feb;51(1):233-259. doi: 10.1214/22-aos2248. Epub 2023 Mar 23.
3
Zero-inflated Poisson models with measurement error in the response.带有响应测量误差的零膨胀泊松模型。
Biometrics. 2023 Jun;79(2):1089-1102. doi: 10.1111/biom.13657. Epub 2022 Apr 20.
4
Transfer Learning for High-Dimensional Linear Regression: Prediction, Estimation and Minimax Optimality.高维线性回归的迁移学习:预测、估计与极小极大最优性
J R Stat Soc Series B Stat Methodol. 2022 Feb;84(1):149-173. doi: 10.1111/rssb.12479. Epub 2021 Nov 16.
5
Thyroid Hormone Receptor Beta as Tumor Suppressor: Untapped Potential in Treatment and Diagnostics in Solid Tumors.甲状腺激素受体β作为肿瘤抑制因子:实体瘤治疗与诊断中的未开发潜力
Cancers (Basel). 2021 Aug 24;13(17):4254. doi: 10.3390/cancers13174254.
6
Seagull: lasso, group lasso and sparse-group lasso regularization for linear regression models via proximal gradient descent.海鸥算法:通过近端梯度下降法实现线性回归模型的套索、组套索和稀疏组套索正则化。
BMC Bioinformatics. 2020 Sep 15;21(1):407. doi: 10.1186/s12859-020-03725-w.
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MALMEM: model averaging in linear measurement error models.MALMEM:线性测量误差模型中的模型平均法
J R Stat Soc Series B Stat Methodol. 2019 Sep;81(4):763-779. doi: 10.1111/rssb.12317. Epub 2019 Jun 2.
8
Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing.单细胞基因组测序揭示乳腺癌拷贝数遗传异质性的新见解。
Elife. 2020 May 13;9:e51480. doi: 10.7554/eLife.51480.
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Mol Cancer. 2015 Jul 5;14:129. doi: 10.1186/s12943-015-0380-7.
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Assessing copy number alterations in targeted, amplicon-based next-generation sequencing data.评估基于扩增子的靶向新一代测序数据中的拷贝数改变。
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