Neutrophil/Lymphocyte Ratio and Monocyte/Lymphocyte Ratio Concerning Renal Injury in Patients with Lupus Nephritis.

BACKGROUND

The aim of this study was to investigate the correlation between the neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/lymphocyte ratio (PLR) with renal injury in patients with lupus nephritis (LN).

METHODS

Data was obtained from 26 patients with LN and 72 with systemic lupus erythematosus (SLE) who received treatment between January 2021 and October 2022 at the First Hospital of Heilongjiang University of Traditional Chinese Medicine. Venous blood was collected from the patients. We determined blood urea, creatinine (Cr), cystatin C (CYSC), and uric acid (UA) and calculated the NLR, MLR, and PLR.

RESULTS

The NLR and MLR were significantly greater in the LN group compared to SLE group (p < 0.05). Spearman's correlation analysis demonstrated that MLR had a positive correlation with UA (p < 0.05), while PLR ex-hibited a positive correlation with Cr and UA (p < 0.05). The NLR and MLR p-values were less than 0.05, and the respective areas under the receiver operating characteristic (ROC) curves for each were 0.761 and 0.720.

CONCLUSIONS

NLR and MLR are strongly related to renal injury in patients with LN. These ratios demonstrate a reasonable correlation with the commonly used markers of renal injury and have significant clinical value in evaluating impaired renal function in such patients.