El-Sehrawy Amr Ali Mohamed Abdelgawwad, Rashid Teeba Ammar, Rodrigues Paul, Gabaal Baneen C, Ballal Suhas, Singh Abhayveer, Krithiga T, Manu Mehul, Esanmurodova N, Abbas Jamal K
Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt.
Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-Maarif, Anbar, Iraq.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jul 15. doi: 10.1007/s00210-025-04387-2.
A collection of illnesses known as rheumatic immune diseases impacts the immune system and causes a range of physiological manifestations. In severe circumstances, these illnesses can raise the chance of death, inflict discomfort, and lower quality of life. Diagnosis and therapy are complicated due to the various illnesses, particular variances, and the disease's unexplained etiology. More investigation is required to offer fresh hints for the treatment of diseases. Illness initiation processes can be more accurately modeled by organoid technology, compensating for animal model variation among species. It has the potential to be a valuable tool for the research of rheumatic immune disorders. It can be a diagnostic tool for novel treatment targets and customized conditions according to patient-derived organoids. As a result, research on organoids and their use in rheumatic immunological disorders is compiled in this article. It also addresses the issues that must be resolved and offers a perspective on the possibilities of organoids in this area, generating fresh concepts for further study of these illnesses.
一系列被称为风湿免疫疾病的病症会影响免疫系统，并引发一系列生理表现。在严重情况下，这些疾病会增加死亡几率、造成不适并降低生活质量。由于疾病种类繁多、存在特殊差异以及病因不明，诊断和治疗都很复杂。需要更多研究来为疾病治疗提供新线索。类器官技术可以更准确地模拟疾病起始过程，弥补不同物种动物模型的差异。它有可能成为研究风湿免疫疾病的宝贵工具。根据患者来源的类器官，它可以作为新型治疗靶点和定制条件的诊断工具。因此，本文汇编了关于类器官及其在风湿免疫疾病中的应用研究。它还讨论了必须解决的问题，并对类器官在该领域的可能性提出了展望，为进一步研究这些疾病产生新的概念。
