肌苷霉素，一种新型氨基糖苷类抗生素复合物。II. 结构测定。

Inosamycin, a complex of new aminoglycoside antibiotics. II. Structure determination.

作者信息

Tsunakawa M, Hanada M, Tsukiura H, Konishi M, Kawaguchi H

出版信息

J Antibiot (Tokyo). 1985 Oct;38(10):1313-21. doi: 10.7164/antibiotics.38.1313.

DOI:10.7164/antibiotics.38.1313

Abstract

Structures of the new aminocyclitol antibiotics, inosamycins A, B, C, D and E, have been determined by a combination of chemical degradation and spectroscopic studies. They are structurally related to neomycin, paromomycin and ribostamycin but differ in that all the inosamycin components contain 2-deoxy-scyllo-inosamine in place of 2-deoxystreptamine in the known aminoglycoside antibiotics.

摘要

新型氨基环醇抗生素肌醇霉素A、B、C、D和E的结构已通过化学降解和光谱研究相结合的方法确定。它们在结构上与新霉素、巴龙霉素和核糖霉素相关，但不同之处在于，所有肌醇霉素组分都含有2-脱氧-scyllo-肌醇胺，以取代已知氨基糖苷类抗生素中的2-脱氧链霉胺。