肌动霉素，一种新型氨基糖苷类抗生素复合物。I. 生产、分离及性质

Inosamycin, a complex of new aminoglycoside antibiotics. I. Production, isolation and properties.

作者信息

Tsunakawa M, Hanada M, Tsukiura H, Tomita K, Tomatsu K, Hoshiya T, Miyaki T, Konishi M, Kawaguchi H

出版信息

J Antibiot (Tokyo). 1985 Oct;38(10):1302-12. doi: 10.7164/antibiotics.38.1302.

DOI:10.7164/antibiotics.38.1302

Abstract

A strain of Streptomyces hygroscopicus No. J296-21 (ATCC 39150) was found to produce a complex of new antibiotics, called inosamycins, which consisted of components A, B, C, D and E. They are novel aminocyclitol antibiotics structurally related to neomycin, paromomycin and ribostamycin. The antibiotic complex and each component of inosamycin exhibit a broad antibacterial spectrum but they are inactive against most of the aminoglycoside-resistant organisms. The antibacterial activity of inosamycin A, the major component of the complex, is comparable to that of neomycin but its acute toxicity is significantly lower (ca. 1/3) than that of neomycin.

摘要

一株吸水链霉菌J296 - 21（ATCC 39150）被发现能产生一种新的抗生素复合物，称为肌醇霉素，它由A、B、C、D和E组分组成。它们是与新霉素、巴龙霉素和核糖霉素结构相关的新型氨基环醇抗生素。该抗生素复合物及肌醇霉素的各组分均表现出广谱抗菌活性，但对大多数耐氨基糖苷类的微生物无活性。该复合物的主要组分肌醇霉素A的抗菌活性与新霉素相当，但其急性毒性明显低于新霉素（约为新霉素的1/3）。