Li Xinqiu, Ma Tiantian, Hao Jiayu, Song Di, Wang Hongyan, Liu Tianjiao, Xu Xiao, Dong Jie
Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health, Ministry of Education; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education; Research Units of Diagnosis and Treatment of Immune-Mediated Kidney Diseases, Chinese Academy of Medical Sciences, Beijing, 100034, China.
BMC Nephrol. 2025 Jul 15;26(1):389. doi: 10.1186/s12882-025-04317-7.
The relationship between exercise and abdominal wall complications remains controversial in the general population and has rarely been studied in patients with peritoneal dialysis (PD). This study aims to investigate the association between exercise and abdominal wall complications in the PD population.
A retrospective data analysis of a prospective cohort. Abdominal wall complications were recorded during follow-up. Exercise characteristics were collected monthly by outpatient questionnaire, including whether the patient exercised, type of exercise, exercise duration, and exercise intensity. Competing risk models were used to evaluate the predictive power of exercise variables for the occurrence of abdominal wall complications.
Among the 475 patients undergoing PD, 33 (6.9%) developed abdominal wall complications during a median follow-up of 46.0 months. A total of 377 (79.4%) patients engaged in regular exercise, with walking (99.5%) being the predominant form. Only 2 (0.5%) patients combined aerobic and resistance exercise. The median exercise duration was 210.0 min per week (interquartile range: 140.0-350.0 min). No exercise characteristics, including exercise participation, exercise duration per week, or exercise intensity, were found to be associated with abdominal wall complications in either univariate or multivariate competing risk analyses. Similarly, exercise variables showed no significant prognostic value in any subgroup analyses.
This study demonstrates for the first time that exercise, primarily in the form of aerobic activity at typical duration and intensity levels, does not increase the risk of abdominal wall complications in PD patients. Further research is needed to explore the effects of high-intensity aerobic exercise and resistance training in the PD population.
This study did not involve any interventions, and all the data were obtained from the PDTAP database (Registration number: NCT03571451; Registration date: 2018-06-20). We adhered to the Declaration of Helsinki.
在普通人群中，运动与腹壁并发症之间的关系仍存在争议，而在腹膜透析（PD）患者中很少进行研究。本研究旨在调查PD人群中运动与腹壁并发症之间的关联。
对一个前瞻性队列进行回顾性数据分析。在随访期间记录腹壁并发症。每月通过门诊问卷收集运动特征，包括患者是否运动、运动类型、运动持续时间和运动强度。使用竞争风险模型评估运动变量对腹壁并发症发生的预测能力。
在475例接受PD治疗的患者中，在中位随访46.0个月期间，33例（6.9%）发生了腹壁并发症。共有377例（79.4%）患者进行规律运动，其中步行（99.5%）是主要形式。只有2例（0.5%）患者同时进行有氧运动和抗阻运动。中位运动持续时间为每周210.0分钟（四分位间距：140.0 - 350.0分钟）。在单因素或多因素竞争风险分析中，未发现任何运动特征，包括运动参与情况、每周运动持续时间或运动强度，与腹壁并发症相关。同样，在任何亚组分析中，运动变量均未显示出显著的预后价值。
本研究首次表明，主要以典型持续时间和强度水平的有氧运动形式进行的运动，不会增加PD患者发生腹壁并发症的风险。需要进一步研究探索高强度有氧运动和抗阻训练对PD人群的影响。
本研究未涉及任何干预措施，所有数据均从PDTAP数据库获得（注册号：NCT03571451；注册日期：2018年6月20日）。我们遵循了《赫尔辛基宣言》。
