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Unveiling new therapeutic targets for esophageal cancer treatment through single-cell transcriptomics: pH-responsive nanobubbles enhance the efficacy of 125I radiotherapy.

作者信息

Wang Yiliang, Zhong BangHua, Chen Xiaoyu, Zhao Yue, Cai Dasheng, Qu Letian, Bai Tao

机构信息

Department of Anesthesiology, The First Hospital of China Medical University, No. 155, Nanjing North Street, Heping District, Shenyang, Liaoning Province, 110001, P. R. China.

Department of Health Statistics, School of Public Health, China Medical University, Shenyang, 110122, PR China.

出版信息

J Nanobiotechnology. 2025 Jul 15;23(1):515. doi: 10.1186/s12951-025-03552-2.

DOI:10.1186/s12951-025-03552-2
PMID:40665303
Abstract
摘要

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Ezetimibe Induces Paraptosis through Niemann-Pick C1-like 1 Inhibition of Mammalian-Target-of-Rapamycin Signaling in Hepatocellular Carcinoma Cells.依泽替米贝通过抑制肝癌细胞中雷帕霉素哺乳动物靶点信号通路的尼曼-匹克C1样1蛋白诱导副凋亡。
Genes (Basel). 2023 Dec 19;15(1):4. doi: 10.3390/genes15010004.
2
Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells.组织蛋白酶 L 抑制增强结肠癌细胞的辐射敏感性。
Int J Mol Sci. 2023 Dec 4;24(23):17106. doi: 10.3390/ijms242317106.
3
Melatonin in Chemo/Radiation Therapy; Implications for Normal Tissues Sparing and Tumor Suppression: An Updated Review.
褪黑素在化疗/放疗中的作用；对正常组织保护和肿瘤抑制的影响：最新综述
Curr Med Chem. 2025;32(3):511-538. doi: 10.2174/0109298673262122231011172100.
4
The bladder cancer immune micro-environment in the context of response to immune checkpoint inhibition.在免疫检查点抑制反应背景下的膀胱癌免疫微环境。
Front Immunol. 2023 Aug 31;14:1235884. doi: 10.3389/fimmu.2023.1235884. eCollection 2023.
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Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment.甲硫氨酸协调顺铂耐药膀胱癌微环境中的代谢脆弱性。
Cell Death Dis. 2023 Aug 15;14(8):525. doi: 10.1038/s41419-023-06050-1.
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Ultra-high dose-rate proton FLASH improves tumor control.超高剂量率质子 FLASH 可提高肿瘤控制率。
Radiother Oncol. 2023 Sep;186:109741. doi: 10.1016/j.radonc.2023.109741. Epub 2023 Jun 12.
7
YTHDF2 inhibition potentiates radiotherapy antitumor efficacy.YTHDF2 抑制增强放疗抗肿瘤疗效。
Cancer Cell. 2023 Jul 10;41(7):1294-1308.e8. doi: 10.1016/j.ccell.2023.04.019. Epub 2023 May 25.
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ScRNA-seq revealed an immunosuppression state and tumor microenvironment heterogeneity related to lymph node metastasis in prostate cancer.单细胞RNA测序揭示了前列腺癌中与淋巴结转移相关的免疫抑制状态和肿瘤微环境异质性。
Exp Hematol Oncol. 2023 May 23;12(1):49. doi: 10.1186/s40164-023-00407-0.
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Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells.通过靶向髓源抑制细胞中的 GPR84 克服免疫疗法的耐药性。
Signal Transduct Target Ther. 2023 Apr 28;8(1):164. doi: 10.1038/s41392-023-01388-6.