Wang Chin-Kun, Li Ke-Xin, Sun Sheng-Qian, Liu Tristan-C
Department of Nutrition, Chung Shan Medical University, Taichung, China.
Le Bonta Wellness Co. Ltd, Shanghai, China.
Front Endocrinol (Lausanne). 2025 Jul 1;16:1629741. doi: 10.3389/fendo.2025.1629741. eCollection 2025.
The clinical application of specialized oral nutritional supplements (ONS) in managing hospitalized patients with diabetes mellitus necessitates rigorous evaluation of their effects on glycemic stability and nutritional parameters. This prospective study aimed to investigate the impact of a diabetes-specific ONS, Complete Nutrition Diabetic Formula, on glycemic control and key nutritional indices in diabetic inpatients. Forty adult inpatients diagnosed with diabetes mellitus requiring nutritional support were enrolled and completed the intervention. Following assessment of individual caloric requirements, participants received an average daily supplementation of 156 g (equivalent to 2.6 packs) of the Complete Nutrition Diabetic Formula over a mean duration of 29 days (range 14-67 days). Glycemic parameters, anthropometric measurements (including mid-arm circumference, MAC), and pertinent biochemical markers (including serum magnesium) were assessed at baseline and study conclusion. Post-intervention analysis showed a higher total caloric and fat intake with a lower carbohydrate share, accompanied by significant gains in mid- arm circumference (MAC), serum magnesium, and a nitrogen-balance flip from -2.7 g/day to +1.25 g/day ( < 0.05), marking a catabolic - to - anabolic shift and confirming protein repletion. Fasting plasma glucose and other biochemical indices - including serum proteins and lipid profiles - remained unchanged ( > 0.05), indicating that short-term Complete Nutrition Diabetic Formula supplementation improves key nutritional indicators without compromising glycemic control or broader metabolic stability.
专用口服营养补充剂(ONS)在糖尿病住院患者管理中的临床应用需要对其对血糖稳定性和营养参数的影响进行严格评估。这项前瞻性研究旨在调查糖尿病专用ONS——全营养糖尿病配方奶粉——对糖尿病住院患者血糖控制和关键营养指标的影响。40名被诊断患有糖尿病且需要营养支持的成年住院患者被纳入并完成了干预。在评估个体热量需求后,参与者平均每天补充156克(相当于2.6包)全营养糖尿病配方奶粉,平均持续29天(范围14 - 67天)。在基线和研究结束时评估血糖参数、人体测量指标(包括上臂围,MAC)和相关生化指标(包括血清镁)。干预后分析显示,总热量和脂肪摄入量增加,碳水化合物占比降低,同时上臂围(MAC)、血清镁显著增加,氮平衡从 - 2.7克/天转变为 + 1.25克/天(<0.05),标志着从分解代谢到合成代谢的转变并证实蛋白质补充充足。空腹血糖和其他生化指标——包括血清蛋白和血脂谱——保持不变(>0.05),表明短期补充全营养糖尿病配方奶粉可改善关键营养指标,而不影响血糖控制或更广泛的代谢稳定性。