Kantarama Evelyne, Uwizeye Dieudonne, Mselle Teddy
Clinical Biology Department, School of Medicine and Pharmacy, College of Medicine and Health Science, University of Rwanda, Kigali, Rwanda.
Development studies, University of Rwanda, Kigali, Rwanda.
Rwanda J Med Health Sci. 2021 Apr 8;4(1):84-97. doi: 10.4314/rjmhs.v4i1.7. eCollection 2021 Apr.
Regular screening for microalbuminuria among type 2 diabetes patients is less common in most low-income countries while it is an early marker of diabetic nephropathy and cardiovascular complications.
This study aims to assess the need for regular screening for microalbuminuria among type 2 diabetes patients.
with cross-sectional approach, 124 diabetic patients were recruited at Muhimbili National Hospital, in Tanzania; their age, gender, body mass index, fasting blood sugar levels (by Accu Chek Active Glucometer), random urine albumin levels (by Microalbumin 2-1 Combo Test Strips), and the duration of diabetes were recorded.
The study indicated that 62.1% of the participants were microalbuminuric while 2.4% were macroalbuminuric. The risk of microalbuminuria was 4.55 higher in patients aged 60-69 years (95% CI: 1.32-16.51), and 17.4 times higher in patients aged 70 and above (95% CI: 1.49-202.86) compared to individuals aged below 50 years. Patients with high blood sugar level had a risk of 8.09 times higher compared to those with normal blood sugar (CI: 2.53-25.86). Also, the odds were 7.89 higher in patients who lived with diabetes for 10-14 years compared to those lived with the disease less than 5 years (95% CI:1.33-45.59).
The odds of microalbuminuria increased significantly as the patient gets older, with high blood sugar, and the duration of diabetes. Health policies need to establish programs that enhance care at the diabetic clinic through regular screening for microalbuminuria to reduce the risk of developing kidney and cardiovascular complications.
在大多数低收入国家,对2型糖尿病患者进行微量白蛋白尿的定期筛查并不常见,而微量白蛋白尿是糖尿病肾病和心血管并发症的早期标志物。
本研究旨在评估2型糖尿病患者定期筛查微量白蛋白尿的必要性。
采用横断面研究方法,在坦桑尼亚的穆希姆比利国家医院招募了124名糖尿病患者;记录了他们的年龄、性别、体重指数、空腹血糖水平(使用Accu Chek Active血糖仪)、随机尿白蛋白水平(使用微量白蛋白2-1组合测试条)以及糖尿病病程。
研究表明,62.1%的参与者存在微量白蛋白尿,2.4%的参与者存在大量白蛋白尿。与50岁以下的个体相比,60-69岁患者微量白蛋白尿的风险高4.55倍(95%置信区间:1.32-16.51),70岁及以上患者的风险高17.4倍(95%置信区间:1.49-202.86)。血糖水平高的患者风险比血糖正常的患者高8.09倍(置信区间:2.53-25.86)。此外,与糖尿病病程小于5年的患者相比,糖尿病病程为10-14年的患者患病几率高7.89倍(95%置信区间:1.33-45.59)。
随着患者年龄增长、血糖升高以及糖尿病病程延长,微量白蛋白尿的几率显著增加。卫生政策需要制定相关项目,通过定期筛查微量白蛋白尿来加强糖尿病诊所的护理,以降低发生肾脏和心血管并发症的风险。