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SymPET,一种用于超高分辨率飞行时间正电子发射断层扫描(TOF PET)的波形数字化“片上系统”:设计概念与初步研究。

SymPET, a waveform digitizing "System on Chip" for ultra-high resolution TOF PET: design concept and preliminary studies.

作者信息

Flood K, Chock C, Blackberg L, Feng Y, Hashemi S, Macchiarulo L, Mishra M, Thelen D, Mostafanezhad I, Sabet H

机构信息

Nalu Scientific LLC, Honolulu, HI, USA.

Department of Radiology, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA.

出版信息

IEEE Nucl Sci Symp Conf Rec (1997). 2022 Nov;2022. doi: 10.1109/nss/mic44845.2022.10398916.

Abstract

SymPET is a low-power, high channel density, waveform-digitizing readout microchip under development at Nalu Scientific for SiPM-based TOF PET applications. Our "System on Chip" waveform digitizing architecture includes features such as fully random accessible analog storage, input triggering, and on-chip biasing, control and waveform feature extraction capabilities, enabling many effective mechanisms to optimize features such as e.g., throughput, speed, and buffer length while simultaneously allowing excellent control of systematic effects which typically significantly affect the timing precision of time-over-threshold based readouts. Preliminary results show that SymPET can provide less than 10 ps timing jitter at a reasonable power budget which is substantially better compared to existing solutions. This will allow for high-channel density and/or limited angle applications such as ultra high resolution brain TOF PET designs that require proper management of heat dissipation, while necessitating high spatial and timing resolution.

摘要

SymPET是一款低功耗、高通道密度的波形数字化读出微芯片,由Nalu Scientific公司正在开发,用于基于硅光电倍增管(SiPM)的飞行时间(TOF)正电子发射断层扫描(PET)应用。我们的“片上系统”波形数字化架构包括完全随机访问的模拟存储、输入触发以及片上偏置、控制和波形特征提取等功能,从而实现了许多有效的机制来优化诸如吞吐量、速度和缓冲长度等特性,同时能够出色地控制那些通常会显著影响基于过阈值读出的定时精度的系统效应。初步结果表明,SymPET在合理的功率预算下可提供小于10皮秒的定时抖动,与现有解决方案相比有显著提升。这将适用于高通道密度和/或有限角度的应用,如超高分辨率脑部TOF PET设计,这类设计需要妥善管理散热,同时又需要高空间和定时分辨率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb1c/12263110/2e56bb13d4a2/nihms-2054993-f0001.jpg

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