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糖尿病足溃疡的多模态重建方法

Multimodal Reconstruction Approaches in Diabetic Foot Ulcers.

作者信息

Lk Vijaykharthik, R Manimaran, Kanchana Koppolu, Sreedevi B V

机构信息

General Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.

Plastic Surgery, Sree Balaji Medical College and Hospital, Chennai, IND.

出版信息

Cureus. 2025 Jun 14;17(6):e86013. doi: 10.7759/cureus.86013. eCollection 2025 Jun.

DOI:10.7759/cureus.86013
PMID:40666571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12261380/
Abstract

INTRODUCTION

Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes mellitus, often leading to prolonged morbidity and limb amputation. Successful management involves early debridement, infection control, and appropriate soft tissue coverage.

METHODS

The present study is a retrospective case series conducted from March 1 to August 31, 2024, involving seven patients with chronic DFUs at Sree Balaji Medical College and Hospital. Each case underwent individualized reconstruction strategies, including split-thickness skin grafts (STSGs), reverse sural artery flaps, medial plantar artery flaps, cross-leg flaps, and conservative healing, depending on wound location, depth, and vascular status.

RESULTS

All patients demonstrated favorable outcomes in terms of graft/flap viability and wound healing. Functional recovery was satisfactory in each case. No major complications or recurrences were observed during follow-up.

CONCLUSION

Early and tailored multimodal reconstructive approaches yield positive outcomes in DFUs. Strategic planning based on anatomical site and biomechanical load is crucial for effective limb salvage.

摘要

引言

糖尿病足溃疡(DFUs)是糖尿病常见且严重的并发症,常导致长期发病和肢体截肢。成功的治疗包括早期清创、感染控制和适当的软组织覆盖。

方法

本研究是一项回顾性病例系列研究,于2024年3月1日至8月31日进行,涉及斯利·巴拉吉医学院和医院的7例慢性糖尿病足溃疡患者。根据伤口位置、深度和血管状况,每个病例都采用了个体化的重建策略,包括断层皮片移植(STSGs)、腓肠神经营养血管逆行皮瓣、足底内侧动脉皮瓣、交腿皮瓣和保守愈合。

结果

所有患者在移植物/皮瓣存活和伤口愈合方面均显示出良好的结果。每个病例的功能恢复都令人满意。随访期间未观察到重大并发症或复发。

结论

早期且量身定制的多模式重建方法在糖尿病足溃疡治疗中产生了积极的结果。基于解剖部位和生物力学负荷的战略规划对于有效的肢体挽救至关重要。

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本文引用的文献

1
Efficacy of two different types of island flaps for the repair of diabetic foot ulcers on the heel.两种不同类型岛状皮瓣修复足跟部糖尿病足溃疡的疗效
Ann Transl Med. 2022 Mar;10(5):256. doi: 10.21037/atm-22-293.
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Challenges in the Treatment of Chronic Wounds.慢性伤口治疗中的挑战。
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Inter-observer reproducibility of diagnosis of diabetic foot osteomyelitis based on a combination of probe-to-bone test and simple radiography.基于探针骨试验和简单放射照相组合的糖尿病足骨髓炎诊断的观察者间重现性。
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Immunonutrition: Role in Wound Healing and Tissue Regeneration.免疫营养:在伤口愈合和组织再生中的作用
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Stem Cells and Healing: Impact on Inflammation.干细胞与愈合:对炎症的影响
Adv Wound Care (New Rochelle). 2013 Sep;2(7):369-378. doi: 10.1089/wound.2013.0449.
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Burden of diabetic foot ulcers for medicare and private insurers.糖尿病足溃疡给医疗保险和私人保险公司带来的负担。
Diabetes Care. 2014;37(3):651-8. doi: 10.2337/dc13-2176. Epub 2013 Nov 1.
8
Advanced therapies for chronic wounds: NPWT, engineered skin, growth factors, extracellular matrices.慢性伤口的高级治疗方法:负压伤口治疗、工程皮肤、生长因子、细胞外基质。
Dermatol Ther. 2013 May-Jun;26(3):215-21. doi: 10.1111/dth.12050.
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Evidence-based management of common chronic lower extremity ulcers.常见慢性下肢溃疡的循证管理。
Dermatol Ther. 2013 May-Jun;26(3):187-96. doi: 10.1111/dth.12051.
10
The GSK-3β/Fyn/Nrf2 pathway in fibroblasts and wounds of type 2 diabetes: On the road to an evidence-based therapy of non-healing wounds.2型糖尿病患者成纤维细胞和伤口中的GSK-3β/Fyn/Nrf2信号通路:迈向非愈合伤口循证治疗之路
Adipocyte. 2012 Jul 1;1(3):161-163. doi: 10.4161/adip.20235.