Kartoumah Anas, Ali Omar, Alomar Talal, Muhajir Mojir, Horani Mohamad
Biomedical Sciences, University of South Florida, Tampa, USA.
Oncology, University of Arizona College of Medicine - Tucson, Tucson, USA.
Cureus. 2025 Jun 14;17(6):e86027. doi: 10.7759/cureus.86027. eCollection 2025 Jun.
Ectopic catecholamine production by non-small cell lung cancer (NSCLC) is exceptionally rare and, to our knowledge, has not been previously reported in the literature. We present the case of a 68-year-old woman with advanced lung adenocarcinoma who presented in hypertensive crisis due to markedly elevated normetanephrine levels. Initial suspicion was for pheochromocytoma, but normal chromogranin A levels suggested a paraneoplastic phenomenon. Despite alpha-adrenergic blockade, the patient's metastatic disease and refractory hypertension contributed to poor treatment tolerance, ultimately necessitating transition to hospice care. This case underscores the importance of considering atypical endocrine manifestations of NSCLC and highlights the challenges of managing advanced cancer complicated by paraneoplastic syndromes.
非小细胞肺癌（NSCLC）异位分泌儿茶酚胺极为罕见，据我们所知，此前文献中尚未有过报道。我们报告一例68岁晚期肺腺癌女性患者，因去甲变肾上腺素水平显著升高而出现高血压危象。最初怀疑为嗜铬细胞瘤，但嗜铬粒蛋白A水平正常提示为副肿瘤现象。尽管进行了α-肾上腺素能阻滞剂治疗，但患者的转移性疾病和难治性高血压导致治疗耐受性差，最终不得不转入临终关怀。该病例强调了考虑NSCLC非典型内分泌表现的重要性，并突出了管理并发副肿瘤综合征的晚期癌症的挑战。
