Bartilotti Matos Francisca, de Sousa Rita, Malheiro Luís
Infectious Diseases Department, Centro Hospitalar, Vila Nova de Gaia, PRT.
Center for Vector and Infectious Diseases, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisbon, PRT.
Cureus. 2025 Jun 15;17(6):e86056. doi: 10.7759/cureus.86056. eCollection 2025 Jun.
Tick-borne lymphadenopathy (TIBOLA) is a rickettsial infection caused by . It has been increasingly identified across Europe. We present the case of TIBOLA with a unique erythematous forehead rash, which hasn't been described before. Four days after a tick bite on the scalp, a woman presented to the emergency department with a painful swelling in the right retroauricular area and a headache. Examination revealed a palpable lymph node and fever. No eschar was observed. Initial serology for common tick-borne infections was negative. Three days later, she returned to the hospital with an erythematous rash on her forehead. Despite not receiving antibiotic treatment, the symptoms resolved spontaneously. A follow-up serum sample, taken six weeks later, showed seroconversion for spotted fever group rickettsia, leading to the diagnosis of TIBOLA. TIBOLA often goes unrecognized due to nonspecific symptoms and the hidden location of eschars. This case emphasizes the importance of considering TIBOLA in tick-borne illness diagnoses in Portugal.
蜱传淋巴结病(TIBOLA)是一种由……引起的立克次体感染。在欧洲,其确诊病例越来越多。我们报告一例伴有独特的前额红斑皮疹的TIBOLA病例,此前尚无相关描述。一名女性头皮被蜱叮咬四天后,因右耳后区域疼痛性肿胀和头痛前往急诊科就诊。检查发现可触及淋巴结且发热,未观察到焦痂。常见蜱传感染的初始血清学检查结果为阴性。三天后,她因前额出现红斑皮疹再次入院。尽管未接受抗生素治疗,症状仍自行缓解。六周后采集的随访血清样本显示斑点热群立克次体血清转化,从而确诊为TIBOLA。由于症状不具特异性且焦痂位置隐匿,TIBOLA常常未被识别。该病例强调了在葡萄牙蜱传疾病诊断中考虑TIBOLA的重要性。