Breidenbach Brianne M, Driscoll Ira, Glittenberg Matthew P, Paulsen Adam J, Fernandes-Taylor Sara, Naren Tarun, Roberts Grant S, Brach Talia L, Jarchow Mackenzie M, Symanski Leah E, Gaul Anna Y, Lose Sarah R, Rivera-Rivera Leonardo A, Johnson Sterling C, Asthana Sanjay, Christian Bradley T, Cook Dane B, Wieben Oliver, Okonkwo Ozioma C
Wisconsin Alzheimer's Disease Research Center Department of Medicine University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Wisconsin Alzheimer's Institute, University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Alzheimers Dement (N Y). 2025 Jul 14;11(3):e70130. doi: 10.1002/trc2.70130. eCollection 2025 Jul-Sep.
Central arterial stiffness and cerebral blood flow (CBF) are inversely related. Poor cardiorespiratory fitness (CRF) and low physical activity (PA) are related to both higher arterial stiffness and lower CBF. The present study examined (i) whether CRF or PA moderate the relationship between arterial stiffness and CBF, and (ii) whether the intensity or the type of PA needs to be considered.
Participants ( = 78, Mean = 64.2±6.14, 72% female) from the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center were categorized into low, average, and high fitness groups based on maximal graded exercise treadmill test performance. PA was assessed using the CHAMPS (Community Health Activities Model Program for Seniors) questionnaire. Based on hours/week, participants were classified as meeting the recommended 2.5 h of moderate intensity PA per week (PA Rec Met). Weekly hours of moderate and low intensity PA were calculated as activities of > 3 or < 3 metabolic equivalents, respectively. Activity type was categorized as exercise-, sports/leisure- and work-related. Arterial stiffness was measured as aortic pulse wave velocity (aoPWV) by 2D phase contrast magnetic resonance imaging (MRI). CBF was assessed by 4D flow MRI in the internal carotid arteries (ICAs), cavernous ICAs, middle cerebral arteries (MCAs), and via two composite measures of total and global flow.
The association between aoPWV and CBF differed by fitness levels, with a negative relationship in the low fitness group and positive relationships in the average and high fitness groups (all s<0.05). Significant moderating effects on the relationships between aoPWV and CBF were also observed for PA Rec Met (all s<0.05), moderate intensity (= 0.05), and exercise-related (all s < 0.02) PA.
Average or high fitness, meeting the PA guidelines, and more specifically, moderate intensity and exercise-related PA seem to attenuate the negative relationship between aoPWV on CBF.
Higher cardiorespiratory fitness (CRF) reduces the negative impact of aortic pulse wave velocity (aoPWV) on cerebral blood flow (CBF)150 min of moderate physical activity (PA) also mitigates this impact, depending on activity typeInnovative methods: use of cardiac magnetic resonance imaging (MRI) for aoPWV assessmentInnovative methods: use of free-breathing acquisition during cardiac MRIInnovative methods: use of cranial 4D flow MRI for CBF assessment.
中心动脉僵硬度与脑血流量（CBF）呈负相关。心肺适能（CRF）差和身体活动（PA）水平低与较高的动脉僵硬度和较低的脑血流量均相关。本研究探讨了（i）CRF或PA是否会调节动脉僵硬度与CBF之间的关系，以及（ii）是否需要考虑PA的强度或类型。
来自威斯康星州阿尔茨海默病预防登记处和威斯康星州阿尔茨海默病研究中心的参与者（n = 78，平均年龄 = 64.2±6.14岁，72%为女性）根据最大分级运动平板试验表现分为低、中、高适能组。使用CHAMPS（老年人社区健康活动模型计划）问卷评估PA。根据每周小时数，参与者被分类为达到每周推荐的2.5小时中等强度PA（PA推荐达标）。中等强度和低强度PA的每周小时数分别按代谢当量>3或<3的活动计算。活动类型分为与运动、体育/休闲和工作相关。通过二维相位对比磁共振成像（MRI）测量动脉僵硬度，以主动脉脉搏波速度（aoPWV）表示。通过四维血流MRI评估颈内动脉（ICA）、海绵窦段ICA、大脑中动脉（MCA）的CBF，并通过总和全局血流的两种综合测量方法进行评估。
aoPWV与CBF之间的关联因适能水平而异，低适能组呈负相关，中适能组和高适能组呈正相关（所有p<0.05）。对于PA推荐达标（所有p<0.05）、中等强度（p = 0.05）和与运动相关的PA（所有p<0.02），也观察到对aoPWV与CBF之间关系的显著调节作用。
中等或高适能、达到PA指南，更具体地说，中等强度和与运动相关的PA似乎会减弱aoPWV与CBF之间的负相关关系。
较高的心肺适能（CRF）可降低主动脉脉搏波速度（aoPWV）对脑血流量（CBF）的负面影响150分钟的中等强度身体活动（PA）也可减轻这种影响，具体取决于活动类型创新方法：使用心脏磁共振成像（MRI）评估aoPWV创新方法：在心脏MRI期间使用自由呼吸采集创新方法：使用头颅四维血流MRI评估CBF
