Amiri Amir Ahmadzadeh, Jafari Reza, Amiri Ali Ahmadzadeh, Rad Hossein Asgari, Daneshvar Fatemeh, Charati Jamshid Yazdani, Amiri Ahmad Ahmadzadeh
Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences and ExpectAid Inc., ON, Canada.
Department of Ophthalmology, Bu Ali Sina Hospital, Mazandaran University of Medical Sciences, ON, Canada.
Oman J Ophthalmol. 2025 Jun 24;18(2):126-132. doi: 10.4103/ojo.ojo_311_21. eCollection 2025 May-Aug.
This study aims to explore the effect of extracts (GbE) on the prevention of posterior capsule opacification (PCO).
This study was a double-blinded, placebo-controlled, single-center randomized clinical trial.
Patients with senile cataracts randomly received GbE supplement capsules at a dose of 200 mg ( = 74) or an identical placebo ( = 70) daily for 6 months after cataract surgery. Patients' follow-ups were scheduled for up to 3 years after cataract surgery. PCO formation (Pearl/Fibrotic) was graded using slit-lamp examinations. The necessity of a Neodymium-doped yttrium aluminum garnet (Nd: YAG) laser capsulotomy was evaluated by patients' complaints of reduced visual acuity imputable to PCO.
A total of 144 patients with a mean age of 64.92 ± 7.77 years were studied. The mean Log MAR visual acuity in the placebo group started to decrease at 12 months ( = 0.003) and remained significantly lower than the GbE group throughout 36 months ( = 0.005). At 1-year postsurgery, a significant difference between the two groups of GbE and Placebo was observed regarding pearl PCO score, but obvious fibrotic PCO score differences occurred 3 years after surgery. The Nd: YAG capsulotomy was performed in six eyes (6.1%) for the GbE group and 18 eyes (20.4%) for the placebo group ( = 0.004) 3 years after the cataract surgery.
Six months of supplementation with GbE was well tolerated and may provide some marginal prevention in the PCO formation. Besides the effect of the GbE in the inhibition of PCO, we also observed a noticeable reduction in the need for Nd: YAG laser capsulotomy.
本研究旨在探讨银杏叶提取物（GbE）对预防后囊膜混浊（PCO）的作用。
本研究为双盲、安慰剂对照、单中心随机临床试验。
老年白内障患者在白内障手术后随机接受每日200毫克的GbE补充胶囊（n = 74）或相同的安慰剂（n = 70），持续6个月。患者在白内障手术后的随访时间长达3年。使用裂隙灯检查对PCO形成（珍珠样/纤维化）进行分级。通过患者因PCO导致视力下降的主诉来评估钕掺杂钇铝石榴石（Nd:YAG）激光囊切开术的必要性。
共研究了144例平均年龄为64.92±7.77岁的患者。安慰剂组的平均Log MAR视力在12个月时开始下降（P = 0.003），并在整个36个月内显著低于GbE组（P = 0.005）。术后1年，两组在珍珠样PCO评分方面存在显著差异，但纤维化PCO评分差异在术后3年才明显出现。白内障手术后3年，GbE组有6只眼（6.1%）进行了Nd:YAG囊切开术，安慰剂组有18只眼（20.4%）进行了该手术（P = 0.004）。
补充GbE 6个月耐受性良好，可能对PCO形成有一定的预防作用。除了GbE对PCO的抑制作用外，我们还观察到Nd:YAG激光囊切开术的需求显著减少。
