Francian Alexandra, Gadam Srinivasa R, Leyba Aidan, Taylor Robert M, Muttil Pavan, Baca Justin T, Chackerian Bryce
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
Department of Emergency Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
bioRxiv. 2025 Jun 28:2025.06.25.661557. doi: 10.1101/2025.06.25.661557.
Although antibodies often exert their effects within the interstitium, the distribution of antibodies within extravascular tissue compartments is not typically measured. Here, IgG titers in peripheral blood and dermal interstitial fluid (ISF) were compared after intramuscular and intradermal immunization with virus-like particle (VLP)-based vaccines. Antibody titers and durability in serum and ISF were similar, indicating that VLP-based vaccines can efficiently elicit strong antibody responses in the skin.
尽管抗体通常在间质中发挥作用，但血管外组织隔室内抗体的分布通常未被测量。在此，在使用基于病毒样颗粒（VLP）的疫苗进行肌肉注射和皮内免疫后，比较了外周血和真皮间质液（ISF）中的IgG滴度。血清和ISF中的抗体滴度和持久性相似，表明基于VLP的疫苗可以在皮肤中有效引发强烈的抗体反应。
