Milstien J B, Walker J R, Petricciani J C
Science. 1977 Jul 29;197(4302):469-70. doi: 10.1126/science.406673.
Four juvenile rhesus monkeys were inoculated with 10(12) plaque-forming units of the bacteriophage phiV1 isolated from live virus vaccines. After phiV1 had been cleared from the blood, DNA's were isolated from the livers and kidneys and analyzed for the presence of bacteriophage by plaque assays, and for the presence of phiV1 DNA by DNA-DNA reassociation kinetics. No evidence was found for persistence of the bacteriophage or for replication of the phage genome in these rhesus monkeys.
给四只幼年恒河猴接种了从活病毒疫苗中分离出的10(12)个噬菌斑形成单位的噬菌体phiV1。在phiV1从血液中清除后，从肝脏和肾脏中分离出DNA，通过噬菌斑测定分析噬菌体的存在情况，并通过DNA-DNA重缔合动力学分析phiV1 DNA的存在情况。在这些恒河猴中未发现噬菌体持续存在或噬菌体基因组复制的证据。
