Levine P H, Leiseca S A, Hewetson J F, Traul K A, Andrese A P, Granlund D J, Fabrizio P, Stevens D A
Arch Virol. 1980;66(4):341-51. doi: 10.1007/BF01320630.
Seventy-two nonhuman primates were entered into a long-term study to evaluate the pathogenicity of Epstein-Barr virus (EBV). Infectious virus was inoculated into 42 rhesus monkeys, 4 chimpanzees and 1 cynomolgus monkey. Immunostimulation or immunosuppression was attempted in 34 of these animals to enhance the oncogenic potential of the virus. Eleven inoculated animals were followed for more than 3 years and two were observed for 8 years. No tumors were observed in any of the animals; however, serological evaluation of the 47 inoculated primates and 25 matched controls indicated that at least 14 rhesus monkeys and the cynomolgus monkey were successfully infected with EBV. The potential use of rhesus monkeys as a model for EBV-induced disease in humans is discussed.
72只非人灵长类动物被纳入一项长期研究，以评估爱泼斯坦-巴尔病毒（EBV）的致病性。将传染性病毒接种到42只恒河猴、4只黑猩猩和1只食蟹猴体内。对其中34只动物尝试进行免疫刺激或免疫抑制，以增强病毒的致癌潜力。11只接种动物被跟踪观察超过3年，2只被观察了8年。在任何动物中均未观察到肿瘤；然而，对47只接种的灵长类动物和25只配对对照进行的血清学评估表明，至少14只恒河猴和那只食蟹猴成功感染了EBV。讨论了将恒河猴用作人类EBV诱导疾病模型的潜在用途。
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