Tripathi Devika, Akram Ramiza, Kumar Raghavendra, Wal Pranay, Kumar Rai Awani, Rai Vinayak, Gupta Tanya
PSIT-Pranveer Singh Institute of Technology (Pharmacy), Kanpur, India.
Rama Dental College, Hospital and Research Centre, Kanpur, India.
Recent Adv Inflamm Allergy Drug Discov. 2025;19(2):244-258. doi: 10.2174/0127722708304103240821072801.
The orofacial mucous membrane is an appealing route for drug delivery to improve both systemic and local treatments. The aim of the present study was to develop an oral dental film loaded with curcumin hydrotropic solid dispersion for sustained drug delivery in the orofacial region. Compared to other dosage forms, films are the most elegant, palatable, and suitable systems for systemic mucosal drug delivery.
A hydrotropic solid dispersion technique utilizing 2 M sodium salicylate was developed to enhance the solubility of curcumin, addressing its poor water solubility. By forming a solid dispersion with a 1:4 ratio through solvent evaporation, the physicochemical properties of the curcumin-loaded system were evaluated.
The utilization of sodium salicylate hydrotrope in a molecular dispersion significantly improved the solubility and bioavailability of curcumin. Subsequently, an oral dental film loaded with hydrotropic solid dispersion was developed using the solvent casting method with HPMC and gelatin as mucoadhesive polymers. Six different films were prepared using polymeric blends with HPMC and gelatin, which showed homogeneity, yellowish colour, and high drug content uniformity of 98.56 ± 3.24, with thickness ranging from 0.16 mm to 0.24 mm. The films exhibited excellent folding endurance and tensile strength for improved patient palatability. studies demonstrated a significant enhancement in curcumin release, reaching a maximum of 94.66% over seven days in the presence of sodium salicylate hydrotrope, following firstorder kinetics. An permeation of Cur-F3 film had a significant effect on mucoadhesion.
Using hydrotropes in oral film formulation is a new and sustainable method for delivering clinically significant curcumin through the oral mucosa. As a result, it is recommended for use in the design of treatments for other dental diseases.
口腔黏膜是一种有吸引力的给药途径，可改善全身和局部治疗效果。本研究的目的是开发一种载有姜黄素助溶固体分散体的口腔牙用薄膜，用于在口腔区域实现药物的持续递送。与其他剂型相比，薄膜是用于全身黏膜给药的最优雅、可口且合适的系统。
开发了一种利用2M水杨酸钠的助溶固体分散技术，以提高姜黄素的溶解度，解决其水溶性差的问题。通过溶剂蒸发形成1:4比例的固体分散体，对载姜黄素体系的理化性质进行了评估。
在分子分散体中使用水杨酸钠助溶剂显著提高了姜黄素的溶解度和生物利用度。随后，以羟丙基甲基纤维素（HPMC）和明胶作为黏膜黏附聚合物，采用溶剂浇铸法制备了载有助溶固体分散体的口腔牙用薄膜。使用HPMC和明胶的聚合物共混物制备了六种不同的薄膜，这些薄膜呈现均匀性、淡黄色，药物含量均匀度高，为98.56±3.24，厚度范围为0.16毫米至0.24毫米。这些薄膜表现出优异的耐折性和拉伸强度，以提高患者的适口性。研究表明，在水杨酸钠助溶剂存在下，姜黄素的释放显著增强，在七天内达到最大值94.66%，符合一级动力学。Cur-F3薄膜的渗透对黏膜黏附具有显著影响。
在口腔薄膜制剂中使用助溶剂是通过口腔黏膜递送具有临床意义的姜黄素的一种新的可持续方法。因此，建议将其用于其他牙科疾病治疗的设计中。
