Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Commission on Higher Education, Ministry of Education, Bangkok, Thailand.
Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand; Center for Medical and Health Technology Assessment (CM-HTA), Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; Center of Pharmaceutical Outcomes Research, Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Center of Pharmaceutical Outcomes Research, Naresuan University, Phitsanulok, Thailand.
J Control Release. 2022 Aug;348:335-345. doi: 10.1016/j.jconrel.2022.05.048. Epub 2022 Jun 9.
Although curcumin is globally recognized for its health benefits, its clinical application has been restricted by its poor aqueous solubility and stability. To overcome these limitations, nanocarrier-based drug delivery systems (NDS) are one of the most effective approaches being extensively explored over the last few decades to improve curcumin's physicochemical and pharmacological effects. Various NDS could provide productive platforms for addressing the formulation challenge of curcumin, but evidence of such systems has not been summarized. This study aimed to systematically review current evidence of lipid and polymer-based NDS for an oral delivery of curcumin focusing on in vivo models and clinical studies. Among the 48 included studies, 3 studies were randomized controlled clinical trials, while 45 studies were animal models. To date, only five curcumin NDS have been studied in healthy volunteers: γ-cyclodextrin, phytosome, liposome, microemulsion and solid dispersion, while most curcumin NDS have been studied in animal models. Most included studies found that NDS could increase oral bioavailability of curcumin as compared to free curcumin. In conclusion, this systematic review showed evidence of the positive effect of NDS for enhancement of oral bioavailability of curcumin. EXECUTIVE SUMMARY: Curcumin is globally recognized for its health benefits, but its clinical application has been limited by its poor aqueous solubility and stability, which causes poor absorption in the gastrointestinal tract (GI tract) via oral administration. Nanocarrier-based drug delivery systems (NDS) are considered as a productive platform to solve the formulation challenge of curcumin, but evidence of such systems has not been summarized. This study aimed to systematically review current evidence of lipid and polymer-based NDS for an oral delivery of curcumin focusing on in vivo models and clinical studies. Overall, most studies found that all studied NDS could increase the absorption of curcumin as compared to free curcumin. Curcumin was rapidly absorbed and exhibited a long residence time after oral administration of curcumin NDS. In summary, this systematic review showed positive impacts of NDS for enhancement of oral absorption of curcumin.
虽然姜黄素因其对健康的益处而在全球范围内得到认可，但由于其水溶性和稳定性差，其临床应用受到限制。为了克服这些限制，基于纳米载体的药物传递系统（NDS）是过去几十年广泛探索的最有效的方法之一，旨在提高姜黄素的物理化学和药理作用。各种 NDS 可以为解决姜黄素的制剂挑战提供有成效的平台，但尚未对这些系统的证据进行总结。本研究旨在系统综述目前关于基于脂质和聚合物的 NDS 用于口服递 delivery 姜黄素的体内模型和临床研究的证据。在纳入的 48 项研究中，有 3 项为随机对照临床试验，而 45 项为动物模型研究。迄今为止，只有 5 种姜黄素 NDS 已在健康志愿者中进行了研究：γ-环糊精、植物素、脂质体、微乳液和固体分散体，而大多数姜黄素 NDS 已在动物模型中进行了研究。大多数纳入的研究发现，与游离姜黄素相比，NDS 可以提高姜黄素的口服生物利用度。总之，本系统综述表明，NDS 对提高姜黄素的口服生物利用度有积极作用。执行摘要：姜黄素因其对健康的益处而在全球范围内得到认可，但由于其水溶性和稳定性差，导致其通过口服途径在胃肠道（GI 道）中的吸收较差。基于纳米载体的药物传递系统（NDS）被认为是解决姜黄素制剂挑战的有效平台，但尚未对这些系统的证据进行总结。本研究旨在系统综述目前关于脂质和聚合物基 NDS 用于口服递 delivery 姜黄素的体内模型和临床研究的证据。总体而言，大多数研究发现，与游离姜黄素相比，所有研究的 NDS 都可以增加姜黄素的吸收。姜黄素 NDS 口服给药后，姜黄素吸收迅速，体内停留时间长。总之，本系统综述表明，NDS 对提高姜黄素的口服吸收具有积极作用。
