美国“指针”研究中的基线认知以及人口统计学、生活方式和心血管危险因素。
Baseline cognition and demographic, lifestyle, and cardiovascular risk factors in US POINTER.
作者信息
Papp Kathryn V, Farias Sarah Tomaszewski, Howard Marjorie, Thro Amber, Ngandu Tiia, Caudle Brad, Sachs Bonnie C, Chan Michelle, Krueger Kristin R, Hartman Elizabeth R T, Lee Athene, York Michele K, Austin Marie T, Demos Kathryn E, Holland Thomas M, Leng Xiaoyan, Raman Rema, Snyder Heather M, Carrillo Maria C, Whitmer Rachel A, Espeland Mark A, Baker Laura D
机构信息
Department of Neurology, Mass General Brigham, Harvard Medical School, Boston, Massachusetts, USA.
Department of Neurology, University of California Davis, Sacramento, California, USA.
出版信息
Alzheimers Dement. 2025 Jul;21(7):e70216. doi: 10.1002/alz.70216.
INTRODUCTION
Validation of the primary cognitive composite and baseline cognitive characteristics are presented for the US-Study-to-Protect-Brain-Health-Through-Lifestyle-Intervention-to-Reduce-Risk (US POINTER).
METHODS
US POINTER is a multicenter, randomized clinical trial of two lifestyle interventions testing cognitive benefit in older adults without significant cognitive impairment but at-risk for decline due to well-established factors. Cognition is measured using a global cognitive composite (US POINTER modified Neuropsychological Test Battery-PmNTB).
RESULTS
The PmNTB is a valid cognitive composite, exhibiting good psychometric properties and tracking with other established outcomes. Among the 2111 enrolled participants (mean age = 68.2 years, 69% women, 31% from race and ethnic minoritized groups), demographic characteristics alone (age, sex, education, race, ethnicity) explained more variance in cognition measured using the PmNTB (25.94%) compared with cardiovascular and family history risk factors combined (added < 3% explained variance).
DISCUSSION
In a large diverse older adult cohort, demographic features rather than well-established risks for cognitive decline correlate with baseline global cognition.
CLINICAL TRIAL REGISTRATION NUMBER
NCT03688126 HIGHLIGHTS: Demographic characteristics explain baseline cognition in at-risk older adults. The POINTER Modified Neuropsychological Test Battery (PmNTB) is a valid measure. Worse cognition tracks with E4+, high HbA1c, current smoking, Framingham heart risk.
介绍
本文展示了美国通过生活方式干预降低风险以保护脑健康研究（US POINTER）中主要认知综合指标的验证及基线认知特征。
方法
US POINTER是一项多中心随机临床试验，对两种生活方式干预措施进行测试，以评估其对无明显认知障碍但因既定因素有认知衰退风险的老年人的认知益处。认知通过一个整体认知综合指标（US POINTER改良神经心理测试组合-PmNTB）进行测量。
结果
PmNTB是一个有效的认知综合指标，具有良好的心理测量特性，并与其他既定结果相关。在2111名入组参与者中（平均年龄=68.2岁，69%为女性，31%来自种族和族裔少数群体），仅人口统计学特征（年龄、性别、教育程度、种族、族裔）对使用PmNTB测量的认知差异的解释比例（25.94%）高于心血管和家族病史风险因素之和（额外解释的差异<3%）。
讨论
在一个多样化的老年人群队列中，与认知衰退相关的是人口统计学特征而非既定的风险因素与基线整体认知相关。
临床试验注册号
NCT03688126要点：人口统计学特征可解释有风险的老年人的基线认知情况。POINTER改良神经心理测试组合（PmNTB）是一种有效的测量方法。认知较差与携带E4+、高糖化血红蛋白、当前吸烟、弗雷明汉心脏风险相关。
Zotero 插件