Bhaskar Nidhi, Abul Yasin, DeVone Frank, McConeghy Kevin W, Leonard Tayler, Halladay Christopher W, Gravenstein Stefan, Rudolph James L
Center of Innovation in Long Term Services and Supports, Providence VA Medical Center, Providence, Rhode Island, USA.
Division of Geriatric and Palliative Medicine, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
J Infect Dis. 2025 Jul 16;232(Supplement_1):S29-S36. doi: 10.1093/infdis/jiaf151.
Identified in 2001, human metapneumovirus (hMPV) infection can lead to hospitalization and death, especially in older adults and children.
This retrospective, propensity-matched study compared cases of hMPV infection with cases of influenza virus and respiratory syncytial virus (RSV) infection for hospitalization and death outcomes in older adults living in Community Living Centers (CLCs), nursing homes operated by the US Department of Veterans Affairs. We evaluated electronic medical records from July 2017 to June 2024. We included CLC residents with laboratory-confirmed hMPV, influenza virus, or RSV infections. The propensity-matched analysis balanced demographic and clinical characteristics. Proportional hazards models estimated the risk of hospitalization, death or the combined outcome over the 90 days after diagnosis.
We identified 178 hMPV, 1379 influenza virus, and 681 RSV laboratory-confirmed infections. In the propensity analysis. Residents with hMPV infection (n = 173) were well matched to those with influenza virus infection (n = 746). The matched cohort proportional hazard analysis (hMPV vs influenza virus infection) showed similar hazards for 90-day outcomes of hospitalization (adjusted hazard ratio, 1.00 [95% confidence interval, .67-1.49]), death (0.79 [.48-1.29]), or both combined (0.81 [.58-1.12]). With use of similar methods, residents with hMPV (n = 170) were well matched to those with RSV (n = 437). The matched cohort proportional hazard analysis showed similar 90-day outcomes of hospitalization (adjusted hazard ratio, 1.00 [95% confidence interval, .66-1.51)], death (0.93 [.58-1.56], or both combined (0.97 [.68-1.37]).
Resident infection with hMPV produced similar likelihoods of hospitalization and death as infection with influenza virus or RSV. Increased understanding of hMPV and appropriate testing are needed to accurately detect, prevent, and manage hMPV in nursing homes.
人类偏肺病毒（hMPV）于2001年被发现，其感染可导致住院和死亡，尤其是在老年人和儿童中。
这项回顾性、倾向匹配研究比较了hMPV感染病例与流感病毒和呼吸道合胞病毒（RSV）感染病例在居住于社区生活中心（CLC）（由美国退伍军人事务部运营的疗养院）的老年人中的住院和死亡结局。我们评估了2017年7月至2024年6月的电子病历。我们纳入了实验室确诊为hMPV、流感病毒或RSV感染的CLC居民。倾向匹配分析平衡了人口统计学和临床特征。比例风险模型估计了诊断后90天内的住院风险、死亡风险或综合结局风险。
我们确定了178例hMPV、1379例流感病毒和681例RSV实验室确诊感染病例。在倾向分析中，hMPV感染居民（n = 173）与流感病毒感染居民（n = 746）匹配良好。匹配队列比例风险分析（hMPV与流感病毒感染）显示，90天住院结局（调整后风险比，1.00 [95%置信区间，.67 - 1.49]）、死亡结局（0.79 [.48 - 1.29]）或两者综合结局（0.81 [.58 - 1.12]）的风险相似。使用类似方法，hMPV感染居民（n = 170）与RSV感染居民（n = 437）匹配良好。匹配队列比例风险分析显示，90天住院结局（调整后风险比，1.00 [95%置信区间，.66 - 1.51]）、死亡结局（0.93 [.58 - 1.56]）或两者综合结局（0.97 [.68 - 1.37]）相似。
hMPV感染的居民与流感病毒或RSV感染的居民住院和死亡的可能性相似。需要加强对hMPV的了解并进行适当检测，以便在疗养院中准确检测、预防和管理hMPV。
