Aminisani Nayyereh, Fanslow Briony, Wood Timothy, Jelley Lauren, Thorn Louise, Seeds Ruth, Wong Conroy, Trenholme Adrian, Grant Cameron C, Huang Q Sue
Institute of Environmental Science and Research, Wellington, New Zealand.
University of Auckland, Auckland, New Zealand.
J Infect Dis. 2025 Jul 16;232(Supplement_1):S47-S58. doi: 10.1093/infdis/jiaf150.
Understanding temporal trends of influenza and human metapneumovirus (HMPV) infections among adults and their return after the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (coronavirus disease 2019 [COVID-19]) pandemic is important for designing prevention and control strategies.
Using the New Zealand hospital-based surveillance dataset, we compared the population-based incidence, seasonality, and clinical characteristics of influenza and HMPV infections among hospitalized adults aged 20 years and older with acute respiratory infections (ARI) in Auckland, New Zealand, from 2012 to 2023.
In the surveillance project, 37 185 ARI hospitalizations were detected from 2012 to 2023 among adults 20 years and older. Of the 21 649 illnesses tested for HMPV, 735 (3.4%) were positives and of the 24 138 tested for influenza, 3623 (15.0%) were positives. Crude rates of annual ARI hospitalizations per 100 000 adult residents were 9.7 (95% confidence interval [CI], 9-10.4) for HMPV and 48.2 (95% CI, 46.6-49.7) for influenza. The highest hospitalization rates for both viruses were in those aged 80 years or older, those of Māori or Pacific ethnicity, and those living in low socioeconomic status areas. There were no statistically significant differences in the HMPV-associated ARI hospitalization rates before and after the COVID-19 pandemic. In contrast, influenza-associated hospitalization rates per 100 000 were 43.0 before the pandemic, increased to 54.4 in 2022, and then 79.5 in 2023, with significant increases across most demographic groups.
Although HMPV infections accounted for fewer ARI hospitalizations than influenza infections in all study years, relative to younger adults, HMPV-associated ARI hospitalization rates were significantly higher in older adults due to the high prevalence of underlying chronic conditions in this age group. This highlights a need for vaccine/antiviral intervention.
了解成人中流感和人偏肺病毒（HMPV）感染的时间趋势及其在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）（冠状病毒病2019 [COVID-19]）大流行后的回归情况，对于制定预防和控制策略至关重要。
利用新西兰基于医院的监测数据集，我们比较了2012年至2023年新西兰奥克兰20岁及以上患有急性呼吸道感染（ARI）的住院成人中流感和HMPV感染的人群发病率、季节性和临床特征。
在该监测项目中，2012年至2023年期间，20岁及以上成人中有37185例ARI住院病例被检测到。在21649例检测HMPV的病例中，735例（3.4%）呈阳性；在24138例检测流感的病例中，3623例（15.0%）呈阳性。每10万成年居民中每年ARI住院的粗发病率，HMPV为9.7（95%置信区间[CI]，9 - 10.4），流感为48.2（95% CI，46.6 - 49.7）。两种病毒的最高住院率出现在80岁及以上人群、毛利族或太平洋族裔人群以及生活在社会经济地位较低地区的人群中。COVID-19大流行前后，HMPV相关的ARI住院率没有统计学上的显著差异。相比之下，每10万人中流感相关的住院率在大流行前为43.0，2022年增至5
