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2型糖尿病(T2DM)发病风险中的性别差异:对巴基斯坦拉瓦尔品第一个低收入定居点的芬兰糖尿病风险评分(FINDRISC)及疾病管理障碍的可行性评估

Sex differences in risk of developing Type 2 Diabetes Mellitus (T2DM): A feasibility assessment of FINDRISC scoring and barriers to disease management in a low-income settlement of Rawalpindi, Pakistan.

作者信息

Ahmad Taimoor, Tauqir Aisha, Tariq Heena, Qureshi Asra, Jalaluddin Shirin, I Khan Unab, Lokhandwala Naaznin, Khan Adnan Ahmad, Khan Ayesha

机构信息

Akhter Hameed Khan Foundation (AHKF), Islamabad, Pakistan.

Research and Development Solutions (RADS), Islamabad, Pakistan.

出版信息

PLOS Glob Public Health. 2025 Jul 16;5(7):e0003087. doi: 10.1371/journal.pgph.0003087. eCollection 2025.

DOI:10.1371/journal.pgph.0003087
PMID:40668778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12266448/
Abstract

Type 2 Diabetes Mellitus (T2DM) is a growing global public health concern, especially in Pakistan where an estimated 33 million people (aged 20-79 years) have diabetes. This pilot study explores T2DM risk using FINDRISC scoring, and examines participants' knowledge, attitudes, and costs of care related to T2DM across sexes.Adult participants (aged 25-65 years) residing in a low-income neighborhood in Rawalpindi, Pakistan were selected using multi-stage cluster sampling. Data was collected via SurveyCTO® software-based questionnaire, incorporating the standardized FINDRISC tool and questions assessing diabetes-related knowledge, management practices, and the costs associated with disease management. Standardized anthropometric measurements were obtained for all individuals. Descriptive analysis, cross tabulations by sexes, Chi-square, and Fisher Exact probability tests were performed using Stata 17. The study included 260 participants (84 men, 176 women) with a mean age of 41 ± 11.8 years. Anthropometric measures revealed obesity in 44% and elevated waist circumference in 45% of men and 83% of women. Based on FINDRISC scoring, 9 (13%) men and 30 (30%) women exhibited a high risk of developing T2DM (p < 0.01). Despite demonstrating higher knowledge and positive self-management practices towards diabetes, a higher proportion of women were classified as high and very high risk of developing T2DM compared to men (30% vs 13%, p < 0.01). Among self-reported cases of T2DM (49 participants), only 63% reported paying for their treatment, with women reporting higher average monthly expenditures than men, though differences were not statistically significant. Hence, despite higher knowledge and positive self-management practice toward diabetes, women are at greater risk of developing T2DM. The findings suggest the need for expanded community testing using the FINDRISC tool T2DM risk assessment in low-income settings and linking high-risk individuals to healthcare providers. Additionally, targeted health awareness campaigns among poor urban residents, particularly addressing socio-cultural barriers that increase T2DM risk among women, are recommended.

摘要

2型糖尿病(T2DM)是一个日益严重的全球公共卫生问题,在巴基斯坦尤为突出,估计有3300万人(年龄在20 - 79岁之间)患有糖尿病。这项试点研究使用芬兰糖尿病风险评分(FINDRISC)来探究T2DM风险,并考察了不同性别的参与者关于T2DM的知识、态度以及护理成本。

采用多阶段整群抽样的方法,选取了居住在巴基斯坦拉瓦尔品第一个低收入社区的成年参与者(年龄在25 - 65岁之间)。通过基于SurveyCTO®软件的问卷收集数据,问卷纳入了标准化的FINDRISC工具以及评估糖尿病相关知识、管理实践和疾病管理相关成本的问题。对所有个体进行了标准化人体测量。使用Stata 17进行描述性分析、按性别进行交叉制表、卡方检验和Fisher精确概率检验。该研究纳入了260名参与者(84名男性,176名女性),平均年龄为41 ± 11.8岁。人体测量结果显示,44%的男性和45%的男性以及83%的女性存在肥胖问题,45%的男性和83%的女性腰围升高。根据FINDRISC评分,9名(13%)男性和30名(30%)女性表现出患T2DM的高风险(p < 0.01)。尽管女性对糖尿病表现出更高的知识水平和积极的自我管理实践,但与男性相比,被归类为患T2DM高风险和极高风险的女性比例更高(30%对13%,p < 0.01)。在自我报告的T2DM病例(49名参与者)中,只有63%报告支付了治疗费用,女性报告的平均每月支出高于男性,尽管差异无统计学意义。因此,尽管女性对糖尿病有更高的知识水平和积极的自我管理实践,但她们患T2DM的风险更大。研究结果表明,在低收入环境中需要使用FINDRISC工具进行更广泛的社区T2DM风险评估测试,并将高风险个体与医疗服务提供者联系起来。此外,建议针对城市贫困居民开展有针对性的健康意识宣传活动,特别是解决增加女性T2DM风险的社会文化障碍。

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