Cohen B M, Waternaux C, Chouinard G, Sommer B R, Jones B
J Clin Psychopharmacol. 1985 Dec;5(6):328-32.
Depot forms of fluphenazine are frequently used in the outpatient treatment of psychiatric patients. To gather relevant data on pharmacokinetic characteristics of depot fluphenazines, the authors measured plasma levels of neuroleptic activity in 76 clinic patients on stable dosage regimens of fluphenazine decanoate or fluphenazine enanthate. Dose and plasma neuroleptic activity level were highly correlated for both forms of depot fluphenazine. Furthermore, the slope of the regression of log dose to the log plasma neuroleptic activity was the same for both drug forms. However, doses of enanthate twice those of decanoate were associated with the same mean plasma level of neuroleptic activity. Finally, while blood levels of drug overlapped markedly in cohorts of patients receiving different doses of depot medication, the assumption of recent studies that, on the average, patients in such cohorts have different blood and tissue levels of drug was confirmed.
氟奋乃静长效制剂常用于精神科患者的门诊治疗。为收集有关氟奋乃静长效制剂药代动力学特征的相关数据，作者测定了76例使用癸酸氟奋乃静或庚酸氟奋乃静稳定剂量方案的门诊患者的血浆抗精神病活性水平。两种长效氟奋乃静制剂的剂量与血浆抗精神病活性水平均高度相关。此外，两种药物制剂的对数剂量与对数血浆抗精神病活性回归斜率相同。然而，庚酸酯剂量是癸酸酯剂量的两倍时，其抗精神病活性的平均血浆水平相同。最后，虽然接受不同剂量长效药物治疗的患者群体中药物血药浓度有明显重叠，但近期研究认为这些患者群体平均而言血液和组织中的药物水平不同这一假设得到了证实。
