Turbott J, Villiger J, Hunter L
Br J Psychiatry. 1985 Apr;146:439-42. doi: 10.1192/bjp.146.4.439.
Twenty-six chronic schizophrenic patients on well established depot neuroleptic regimes with stable doses (16 on fluphenazine decanoate, ten on flupenthixol decanoate) had serum neuroleptic levels measured by a radioreceptor assay (RRA) method. The assay was sufficiently sensitive to measure serum levels in all cases, with acceptable levels of inter-assay variation. Blood level measurements were repeated on two occasions, at the same time interval from the last injection, in 18 patients (11 on fluphenazine decanoate, seven on flupenthixol decanoate) and remained reasonably stable in most cases, although others showed a wider variation. Despite a wide range of doses (X 32 fluphenazine decanoate, X 21 flupenthixol decanoate) the serum levels fell in a remarkably narrow range (X 4, X 6). There was a significant correlation between dose and blood level for flupenthixol decanoate, but not for fluphenazine decanoate.
26名长期使用长效抗精神病药物且剂量稳定的慢性精神分裂症患者（16名使用癸酸氟奋乃静，10名使用癸酸氟哌噻吨）通过放射受体分析法（RRA）测定了血清抗精神病药物水平。该分析方法灵敏度足以测定所有病例的血清水平，批间变异水平可接受。18名患者（11名使用癸酸氟奋乃静，7名使用癸酸氟哌噻吨）在距上次注射相同时间间隔进行了两次血药浓度测量，多数情况下血药浓度保持相对稳定，尽管其他患者显示出较大波动。尽管剂量范围较宽（癸酸氟奋乃静为32倍，癸酸氟哌噻吨为21倍），血清水平却落在非常窄的范围内（癸酸氟奋乃静为4倍，癸酸氟哌噻吨为6倍）。癸酸氟哌噻吨的剂量与血药浓度之间存在显著相关性，但癸酸氟奋乃静不存在。
