Horner K C, Lenoir M, Bock G R
J Acoust Soc Am. 1985 Nov;78(5):1603-11. doi: 10.1121/1.392798.
The acoustic intermodulation distortion product (2f1-f2) was recorded in the ear canal of two different types of normally hearing mice and in four different types of hearing-impaired mutant mice. In the normally hearing animals, primary tones at levels of 60- to 100-dB SPL evoked distortion product emissions (DP's) at 20-50 dB below the primary levels. In the hearing-impaired mutants the level was dependent on the particular type of auditory dysfunction associated with the mutation. In both the deafness and the viable dominant spotting mutants, where either the whole organ of Corti or the stria vascularis is affected by the mutation, no DP's could be detected. The quivering mutant has a central auditory dysfunction associated with the nuclei of the superior olivary complex and the lateral lemniscus, with apparently normal cochlear function. DP's at levels and thresholds similar to those in normally hearing animals were recorded in quivering mice. The Bronx Waltzer mutant has a full complement of outer hair cells but only about of 20%-25% inner hair cells. DP's of small amplitude were recorded but the thresholds were raised by about 30 dB. The data suggest that the 2f1-f2 emission can be used as a noninvasive monitor of cochlear function.
在两种不同类型的听力正常小鼠以及四种不同类型的听力受损突变小鼠的耳道中记录了声学互调失真产物（2f1 - f2）。在听力正常的动物中，60 - 100 dB SPL水平的初级音调会诱发失真产物发射（DP），其强度比初级音调水平低20 - 50 dB。在听力受损的突变小鼠中，该水平取决于与突变相关的特定听觉功能障碍类型。在耳聋和存活显性斑点突变小鼠中，耳蜗的整个柯蒂氏器或血管纹受到突变影响，未检测到DP。颤抖突变小鼠具有与上橄榄复合体核和外侧丘系相关的中枢听觉功能障碍，耳蜗功能显然正常。在颤抖小鼠中记录到的DP水平和阈值与听力正常的动物相似。布朗克斯华尔兹突变小鼠有完整的外毛细胞，但只有约20% - 25%的内毛细胞。记录到了小幅度的DP，但阈值提高了约30 dB。数据表明，2f1 - f2发射可作为耳蜗功能的非侵入性监测指标。
