Cicek Mehmet Turan, Koca Cigdem Firat, Akarcay Mustafa
Department of Otorhinolaryngology, Inonu University Faculty of Medicine, Malatya, Turkey.
Department of Otorhinolaryngology, Malatya State Hospital, Malatya, Turkey.
North Clin Istanb. 2020 Nov 23;8(1):1-7. doi: 10.14744/nci.2020.10586. eCollection 2021.
Obstructive sleep apnea syndrome (OSAS) is a health problem that has increasing importance in society. In the literature, many studies about an audition in patients with OSAS are present. In this study, the effects of hypoxia on an audition that develop during the apnea attacks in OSAS were investigated experimentally.
This study was conducted in Inonu University Audiology Laboratory after the approval of Inonu University Faculty of Medicine Experimental Animal Research Ethics Committee (Protocol Number: 2011/A-102). In this study, 15 Wistar albino rats with a weight of 250-300 g were used. Anesthesia was performed by 40 mg/kg Ketamine and 5 mg/kg Xylazine through intramuscular administration. The processes were applied in the silence. This study involved 15 rats with normal auditory functions. Only tracheotomy was performed in the control group. Auditory assays were administered with otoacoustic emission (DP gram) before and after the process. In hypoxia group, hypoxia was created by making apnea attacks that lasted at least 10 seconds after the tracheotomy process. Auditory assays using DP gram were performed before tracheotomy and during hypoxia in the hypoxia group.
In the control group, statistically significant values were not found. In the hypoxia group, statistically significant differences were detected in high frequencies.
In conclusion, cochlear reply decreased in high frequencies during hypoxia that was created by apnea attacks.
阻塞性睡眠呼吸暂停综合征（OSAS）是一个在社会中重要性日益增加的健康问题。在文献中，有许多关于OSAS患者听力的研究。在本研究中，通过实验研究了缺氧对OSAS呼吸暂停发作期间发生的听力的影响。
本研究在伊诺努大学医学系实验动物研究伦理委员会批准后（方案编号：2011/A - 102）于伊诺努大学听力学实验室进行。在本研究中，使用了15只体重为250 - 300克的Wistar白化大鼠。通过肌肉注射40毫克/千克氯胺酮和5毫克/千克甲苯噻嗪进行麻醉。实验过程在安静环境中进行。本研究纳入了15只听觉功能正常的大鼠。对照组仅进行气管切开术。在实验过程前后用耳声发射（DP图）进行听觉检测。在缺氧组，气管切开术后通过制造持续至少10秒的呼吸暂停发作来造成缺氧。缺氧组在气管切开术前和缺氧期间使用DP图进行听觉检测。
对照组未发现统计学上的显著差异。缺氧组在高频方面检测到统计学上的显著差异。
总之，由呼吸暂停发作造成的缺氧期间，高频耳蜗反应下降。
