Downes Kevin J, Danziger-Isakov Lara, Varela-Fascinetto Gustavo, Herold Betsy C, Green Michael, L'Huillier Arnaud G
Department of Pediatrics, Perelman School at Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Pediatr Transplant. 2025 Aug;29(5):e70135. doi: 10.1111/petr.70135.
The recently published 4th International Consensus Guidelines on the Management of CMV in Solid-Organ Transplantation offers updated recommendations for CMV prevention, treatment, and monitoring in pediatric solid organ transplant (pSOT) recipients. Although these guidelines are supported by a thorough review of published data, there remain unanswered questions due to a paucity of pediatric data, conflicting findings across studies, or areas where pediatric and adult data are divergent. The current report highlights controversial areas of management, emphasizes the rationale for certain expert opinions, and calls attention to topics that require further research using a case-based approach.
最近发布的《实体器官移植中巨细胞病毒管理的第4版国际共识指南》为小儿实体器官移植（pSOT）受者的巨细胞病毒预防、治疗和监测提供了更新的建议。尽管这些指南得到了对已发表数据的全面审查的支持，但由于儿科数据匮乏、各研究结果相互矛盾或儿科与成人数据存在差异的领域，仍存在未解决的问题。本报告突出了管理中的争议领域，强调了某些专家意见的依据，并通过基于案例的方法提请注意需要进一步研究的主题。
