Meyrick Thomas R H, Browne P D, Kirby J D
J Allergy Clin Immunol. 1985 Dec;76(6):864-9. doi: 10.1016/0091-6749(85)90761-4.
The effect of intradermal ranitidine (administered alone and in combination with clemastine) on allergen-mediated wheal-and-flare reactions has been evaluated in a double-blind study on 10 healthy atopic volunteers. Ranitidine alone, administered in doses over a 10(4)-fold concentration range, had no effect on the size either of allergen-induced wheal or flare reactions. Clemastine alone evoked a dose-related inhibition of both wheal and flare. Compared to the inhibition achieved by clemastine alone, the combination of ranitidine with clemastine produced a small but significant increase in inhibition of allergen-induced flare at ranitidine concentrations of 10(-5) mol/L (p less than 0.001) and 10(-6) mol/L (p less than 0.01), and of allergen-induced wheal at ranitidine concentration 10(-5) mol/L (p less than 0.01). Our results provide further evidence for the presence of cutaneous histamine H2 receptors and their participation in the formation of allergen-mediated skin reactions but indicate that the contribution of cutaneous histamine H2-receptor stimulation to the production of immediate wheal-and-flare reactions evoked by allergen is only modest.
在一项针对10名健康特应性志愿者的双盲研究中，评估了皮内注射雷尼替丁（单独使用以及与氯马斯汀联合使用）对变应原介导的风团及潮红反应的影响。单独使用雷尼替丁，在超过10⁴倍的浓度范围内给药，对变应原诱导的风团或潮红反应的大小均无影响。单独使用氯马斯汀可引起与剂量相关的风团和潮红抑制。与单独使用氯马斯汀所达到的抑制效果相比，雷尼替丁与氯马斯汀联合使用时，在雷尼替丁浓度为10⁻⁵mol/L（p<0.001）和10⁻⁶mol/L（p<0.01）时，对变应原诱导的潮红的抑制作用有小幅但显著的增加，在雷尼替丁浓度为10⁻⁵mol/L（p<0.01）时，对变应原诱导的风团的抑制作用也有增加。我们的结果为皮肤组胺H2受体的存在及其参与变应原介导的皮肤反应的形成提供了进一步的证据，但表明皮肤组胺H2受体刺激对变应原诱发的即刻风团及潮红反应产生的贡献仅为中等程度。
