雷尼替丁单独及与氯马斯汀联合使用对组胺介导的人体皮肤风团和潮红反应的影响。
The influence of ranitidine, alone and in combination with clemastine, on histamine-mediated cutaneous weal and flare reactions in human skin.
作者信息
Thomas R H, Browne P D, Kirby J D
出版信息
Br J Clin Pharmacol. 1985 Oct;20(4):377-82. doi: 10.1111/j.1365-2125.1985.tb05080.x.
Significant, (P less than 0.05) inhibition of histamine induced cutaneous weal and flare reactions by ranitidine at 10(-5) M concentration has been demonstrated in a double blind, in vivo study; the results support the evidence for cutaneous H2-histamine receptors provided by previous studies using cimetidine and metiamide. The degree of inhibition of histamine mediated cutaneous reactions achieved by clemastine was increased by the administration of clemastine and ranitidine together, for ranitidine concentrations 10(-5) M (P less than 0.001) and 10(-6) M (P less than 0.05). The magnitude of the inhibitory effect of ranitidine, both administered alone and in combination with clemastine, suggests that in the production of histamine induced cutaneous weal and flare reactions, the contribution afforded by stimulation of cutaneous H2-histamine receptors is only small.
在一项双盲体内研究中已证实，雷尼替丁在浓度为10⁻⁵M时对组胺诱导的皮肤风团和潮红反应有显著抑制作用（P小于0.05）；这些结果支持了先前使用西咪替丁和甲硫米特的研究所提供的关于皮肤H2组胺受体的证据。对于雷尼替丁浓度为10⁻⁵M（P小于0.001）和10⁻⁶M（P小于0.05）的情况，同时给予氯马斯汀可增强氯马斯汀对组胺介导的皮肤反应的抑制程度。单独给予雷尼替丁以及与氯马斯汀联合使用时，雷尼替丁的抑制作用强度表明，在组胺诱导的皮肤风团和潮红反应的产生过程中，刺激皮肤H2组胺受体所起的作用很小。
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