Leal Miguel A, Sheldon Todd, Escalante Keelia, Holm Mikayle, Galarneau Michelle, Rosemas Sarah, Stromberg Kurt, Piccini Jonathan P
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Cardiac Rhythm Management, Medtronic, Inc., Mounds View, MN, USA.
Future Cardiol. 2025 Aug;21(10):753-758. doi: 10.1080/14796678.2025.2527466. Epub 2025 Jul 16.
Leadless ventricular pacemakers have been developed for single chamber VVIR and AV synchronous pacing applications.
To assess the device longevity impact of battery/electronics enhancements of next-generation Micra leadless pacemakers, Micra VR2 and AV2, compared to Micra VR and AV.
Real-world pacing data gathered from the Micra IDE study, Medtronic's CareLink database, and historical pacemaker patient survival data from Medtronic's Device Registry were used to project device longevity and estimate the proportion of patients requiring lifetime device replacements.
Based on data from 644 patients, the median projected longevity of Micra VR was 12.3 years and Micra VR2 was 16.7 years, with 91% of patients requiring a single VR2 device over their lifetime. Based on data from 999 patients, the median projected longevity of Micra AV was 10.8 years and Micra AV2 was 15.6 years, with 80% of patients requiring one AV2 device. The longevity improvements with Micra VR2 projected 8 fewer device replacements would be required across 100 patients. Similarly, 15 devices would be avoided when considering Micra AV versus AV2.
Modeling of the Micra leadless pacemakers projected meaningful improvements in device longevity and an increase in the number of patients served with a single device.
无导线心室起搏器已被开发用于单腔VVIR和房室同步起搏应用。
评估与Micra VR和AV相比，下一代Micra无导线起搏器Micra VR2和AV2的电池/电子设备增强对设备使用寿命的影响。
从Micra IDE研究、美敦力CareLink数据库收集的实际起搏数据，以及美敦力设备注册中心的历史起搏器患者生存数据，用于预测设备使用寿命，并估计需要终身更换设备的患者比例。
基于644例患者的数据，Micra VR的预计中位使用寿命为12.3年，Micra VR2为16.7年，91%的患者一生中需要一个VR2设备。基于999例患者的数据，Micra AV的预计中位使用寿命为10.8年，Micra AV2为15.6年，80%的患者需要一个AV2设备。Micra VR2的使用寿命改善预计100例患者中需要更换的设备将减少8个。同样，考虑Micra AV与AV2时，将避免15次设备更换。
对Micra无导线起搏器的建模预测设备使用寿命有显著改善，且使用单个设备服务的患者数量增加。
