Tang Ting, Fan Hua, Yu Qingwen, Rao Xiyun, Shi Yongmin, Tong Xuhan, Feng Lanlan, Xu Zhao, Fu Xinyan, Chen Juan, Zhang Xingwei, Tang Jiake, Wang Hu, Wang Mingwei
Department of Cardiology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, Zhejiang, 310015, People's Republic of China.
School of Clinical Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, 471003, People's Republic of China.
Risk Manag Healthc Policy. 2025 Jul 12;18:2387-2399. doi: 10.2147/RMHP.S524872. eCollection 2025.
Metabolic disease-associated fatty liver disease has brought significant challenges to public health and social-economics. There is a need for a straightforward and effective method to screen for metabolic disease-associated fatty liver disease. The weight-adjusted waist circumference index offers a comprehensive reflection of visceral fat accumulation and skeletal muscle loss. This study aims to explore the relationship between weight-adjusted waist circumference index and hepatic steatosis and hepatic fibrosis.
This single-centered study screened 288 participants from the outpatient department of the Affiliated Hospital of Hangzhou Normal University (Hangzhou, China). Multiple linear regression models were utilized to assess the association between weight-adjusted waist circumference index and hepatic steatosis and hepatic fibrosis. The subgroup analysis was carried out according to sex, smoking, drinking, BMI, cardiovascular disease, diabetes and hypertension.
Metabolic disease-associated fatty liver disease was diagnosed in 185 out of 288 patients. Multivariate linear regression analysis indicated a positive linear correlation between weight-adjusted waist circumference index and hepatic steatosis and hepatic fibrosis (P < 0.05). Analysis of subgroups revealed a stronger positive correlation between weight-adjusted waist circumference index and controlled attenuation parameter among participants aged 18-59 years and smokers (P < 0.05). Positive correlations between weight-adjusted waist circumference index and hepatic fibrosis were observed in participants who were alcohol consumers, male, had a body mass index of >28, and with diabetes (P < 0.05).
We report a significant linear positive correlation between weight-adjusted waist circumference index and metabolic disease-associated fatty liver disease, suggesting that weight-adjusted waist circumference index is a potential indicator for metabolic disease-associated fatty liver disease screening.
代谢性疾病相关脂肪性肝病给公共卫生和社会经济带来了重大挑战。需要一种直接有效的方法来筛查代谢性疾病相关脂肪性肝病。体重调整腰围指数能全面反映内脏脂肪堆积和骨骼肌丢失情况。本研究旨在探讨体重调整腰围指数与肝脂肪变性及肝纤维化之间的关系。
这项单中心研究从杭州师范大学附属医院（中国杭州）门诊筛选了288名参与者。采用多元线性回归模型评估体重调整腰围指数与肝脂肪变性及肝纤维化之间的关联。根据性别、吸烟、饮酒、体重指数、心血管疾病、糖尿病和高血压进行亚组分析。
288例患者中有185例被诊断为代谢性疾病相关脂肪性肝病。多因素线性回归分析表明，体重调整腰围指数与肝脂肪变性及肝纤维化呈正线性相关（P<0.05）。亚组分析显示，在18 - 59岁的参与者和吸烟者中，体重调整腰围指数与受控衰减参数之间的正相关性更强（P<0.05）。在饮酒者、男性、体重指数>28以及患有糖尿病的参与者中，体重调整腰围指数与肝纤维化呈正相关（P<0.05）。
我们报告体重调整腰围指数与代谢性疾病相关脂肪性肝病之间存在显著的线性正相关，表明体重调整腰围指数是代谢性疾病相关脂肪性肝病筛查的一个潜在指标。
