Tariq Ansa, Khan Marium Nadeem, Jamali Ayesha Ghazal, Amir Basra Manaal, Mahato Aakash, Imran Syed Mariyum, Mohsin Zainab, Singla Shivam, Mirani Imran K, Asmat Uzma, Malik Habiba
Internal Medicine, Lahore Medical and Dental College, Lahore, PAK.
Medicine, Shifa College of Medicine, Islamabad, PAK.
Cureus. 2025 Jun 16;17(6):e86123. doi: 10.7759/cureus.86123. eCollection 2025 Jun.
Many people with hypermobile Ehlers-Danlos syndrome (hEDS) and joint hypermobility spectrum disorder (JHSD) often experience both orthostatic intolerance (OI) and brain fog. They are both clinically significant, even though their direct link has rarely been studied. This research examines whether there is a link between OI symptoms and complaints of poor concentration in patients with hEDS and JHSD.
A study was carried out with 385 individuals who were clinically diagnosed with hEDS or JHSD in Islamabad, Pakistan. Both the Composite Autonomic Symptom Score (COMPASS-31) and the Cognitive Failure Questionnaire (CFQ) were used to collect data. To investigate the relationship between OI problems and cognitive symptoms, a statistical analysis was conducted using SPSS Statistics version 26 (IBM Corp. Released 2019. IBM SPSS Statistics for Windows, Version 26.0. Armonk, NY: IBM Corp.), including Pearson correlation, t-tests, ANOVA, and linear regression. Data were collected from November 15, 2024, to March 25, 2025.
Orthostatic symptoms were present in 249 (65%) of participants, and cognitive changes were reported by 282 (73%). The correlation between OI and CFQ scores was found to be moderate and statistically significant (r = 0.449, p = 0.03). Participants who experienced brain fog often (36%) scored a bit higher on CFQ than others. Although the differences between the groups were found to be significant, the effect sizes were very small (η² = 0.004), which corresponds to practically irrelevant distinctions. In a regression model, it was confirmed that the OI symptoms were significant predictors of cognitive complaints (r = 0.449, p = 0.03).
The researchers found a statistically significant yet low level of association between OI and cognitive complaints in individuals with hEDS and JHSD. These results suggest that autonomic dysfunction may play a role in the cognitive symptoms experienced by this group of individuals. Future objective assessment studies should be conducted to better understand the mechanisms involved and the contributions of psychological and emotional factors.
许多患有可弯曲型埃勒斯-当洛综合征（hEDS）和关节过度活动谱障碍（JHSD）的人经常经历直立不耐受（OI）和脑雾。它们在临床上都很重要，尽管它们之间的直接联系很少被研究。本研究调查了hEDS和JHSD患者的OI症状与注意力不集中主诉之间是否存在联系。
在巴基斯坦伊斯兰堡对385名临床诊断为hEDS或JHSD的个体进行了一项研究。使用综合自主神经症状评分（COMPASS-31）和认知失误问卷（CFQ）收集数据。为了研究OI问题与认知症状之间的关系，使用SPSS Statistics 26版（IBM公司。2019年发布。适用于Windows的IBM SPSS Statistics，版本26.0。纽约州阿蒙克：IBM公司）进行了统计分析，包括Pearson相关性分析、t检验、方差分析和线性回归。数据收集时间为2024年11月15日至2025年3月25日。
249名（65%）参与者存在直立症状，282名（73%）报告有认知变化。发现OI与CFQ评分之间的相关性为中等且具有统计学意义（r = 0.449，p = 0.03）。经常经历脑雾的参与者（36%）在CFQ上的得分比其他人略高。虽然发现组间差异具有统计学意义，但效应量非常小（η² = 0.004），这实际上相当于无关紧要的差异。在回归模型中，证实了OI症状是认知主诉的重要预测因素（r = 0.449，p = 0.03）。
研究人员发现，在hEDS和JHSD个体中，OI与认知主诉之间存在统计学上显著但程度较低的关联。这些结果表明，自主神经功能障碍可能在这组个体经历的认知症状中起作用。未来应进行客观评估研究，以更好地了解其中涉及的机制以及心理和情感因素的作用。
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