Yu Binrui, Wang Nailong, Cai Shanshan, Yan Hao, Sun Shaojia, Wang Siru, Li Ye, Liang Zhengting
College of Pharmacy, Xinjiang Medical University, Urumqi, China.
College of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.
Front Pharmacol. 2025 Jul 2;16:1610623. doi: 10.3389/fphar.2025.1610623. eCollection 2025.
Melanin produced by melanocytes, primarily determines human skin color and protects against ultraviolet radiation. However, excessive melanin deposition can lead to skin conditions such as freckles, age spots, and moles, potentially causing aesthetic concerns and psychological distress. Consequently, there is significant research interest in developing safe and effective whitening products that inhibit melanin synthesis. Bioactive peptides represent a promising compound category that effectively reduces melanin synthesis with minimal side effects. This review explores melanin pigmentation, identifies sources of peptides that inhibit melanin synthesis, and elucidates the mechanisms by which these peptides operate, aiming to contribute to developing novel whitening products.
黑色素细胞产生的黑色素主要决定人类肤色，并抵御紫外线辐射。然而，黑色素过度沉积会导致雀斑、老年斑和痣等皮肤问题，可能引发审美担忧和心理困扰。因此，开发安全有效的抑制黑色素合成的美白产品具有重大的研究意义。生物活性肽是一类很有前景的化合物，能有效减少黑色素合成且副作用最小。本综述探讨黑色素沉着，确定抑制黑色素合成的肽的来源，并阐明这些肽的作用机制，旨在为开发新型美白产品做出贡献。
