Kamath V R, Bhopale M K, Bhide M B
J Helminthol. 1985 Sep;59(3):195-9. doi: 10.1017/s0022149x0000794x.
The immunological responses in hamsters during treatment with mebendazole against Ancylostoma ceylanicum are studied. Indirect haemagglutination (IHA) counterimmunoelectrophoresis (CIEP), passive cutaneous anaphylaxis (PCA), foot pad swelling for immediate (ITH) and delayed (DTH) types of hypersensitivities were employed for measuring the responses. Serum antibody which was 1:32 before treatment increased to the maximum of 1:512 (control 1:128) on the 10th day and it declined subsequently. The CIEP test was positive for 10 days and then became negative. The PCA test was positive throughout the observation period both in the treated and untreated groups. Foot pad swelling for ITH and DTH responses were comparatively more prominent than in the untreated control up to the 20th day and then both decreased simultaneously. The immunological responses remained prominent for a longer period and decreased more slowly in the untreated control group.
研究了用甲苯咪唑治疗锡兰钩虫期间仓鼠的免疫反应。采用间接血凝试验（IHA）、对流免疫电泳（CIEP）、被动皮肤过敏试验（PCA）以及足垫肿胀试验来检测速发型（ITH）和迟发型（DTH）超敏反应。治疗前血清抗体效价为1:32，在第10天升至最高1:512（对照组为1:128），随后下降。CIEP试验在10天内呈阳性，之后转为阴性。在整个观察期内，治疗组和未治疗组的PCA试验均呈阳性。ITH和DTH反应的足垫肿胀在第20天前比未治疗对照组更为明显，随后两者同时下降。未治疗对照组的免疫反应持续时间更长，下降更缓慢。
