Zhu Changchun, Pan Xiaole, Xie Ran, Liu Bin
Department of Neurology, The Third People's Hospital of Hefei (The Third Clinical College of Anhui Medical University) Hefei 230022, Anhui, China.
Am J Transl Res. 2025 Jun 15;17(6):4651-4662. doi: 10.62347/RFBV1794. eCollection 2025.
To investigate the relationship between lipid variability and the risk of recurrence and mortality during the acute phase of ischemic cerebrovascular disease (ICD) in elderly patients.
Clinical data, lipid profiles, and follow-up information were retrospectively collected from 149 elderly ICD patients who underwent at least three lipid measurements (non-baseline) at The Third People's Hospital of Hefei (The Third Clinical College of Anhui Medical University) from May 2021 to May 2024. Lipid indices included low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), and triglycerides (TG). Variability was assessed using standard deviation (SD), coefficient of variation (CV), and variability independent of the mean (VIM). Follow-up concluded in May 2024. Patients were classified into no-recurrence, recurrence, and death groups. Logistic multivariate regression analysis was used to identify risk factors for recurrence and death. Receiver operating characteristic (ROC) curve analyses were applied to assess the predictive value of lipid variability.
Variabilities in LDL-C, HDL-C, TC, and TG were significantly higher in the recurrence and death groups compared to the no-recurrence group. Logistic regression analysis identified lipid variability indices as independent risk factors for recurrence and death. ROC analysis furtherdemonstrated their predictive value.
Variabilities in LDL-C, HDL-C, TC, and TG are independent risk factors for recurrence and death in elderly ICD patients. Combined analysis of lipid variability enhances diagnostic accuracy and may improve the prognostic assessment in this population.
探讨老年缺血性脑血管病（ICD）急性期血脂变异性与复发风险及死亡率之间的关系。
回顾性收集2021年5月至2024年5月在合肥市第三人民医院（安徽医科大学第三临床学院）接受至少三次（非基线）血脂测量的149例老年ICD患者的临床资料、血脂谱和随访信息。血脂指标包括低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、总胆固醇（TC）和甘油三酯（TG）。采用标准差（SD）、变异系数（CV）和均值独立变异系数（VIM）评估变异性。随访于2024年5月结束。将患者分为无复发组、复发组和死亡组。采用多因素logistic回归分析确定复发和死亡的危险因素。应用受试者工作特征（ROC）曲线分析评估血脂变异性的预测价值。
与无复发组相比，复发组和死亡组的LDL-C、HDL-C、TC和TG变异性显著更高。logistic回归分析确定血脂变异性指标为复发和死亡的独立危险因素。ROC分析进一步证实了它们的预测价值。
LDL-C、HDL-C、TC和TG变异性是老年ICD患者复发和死亡的独立危险因素。血脂变异性的联合分析可提高诊断准确性，并可能改善该人群的预后评估。
