Zeng Tao, Chen Zi-Liang, Zhou Yao-Hui, Liu Wei-Qi, Chen Jian, Lu Jian-Hui, Lin Jia-Hao
Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, Guangdong, China.
Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Front Med (Lausanne). 2025 Jul 2;12:1584032. doi: 10.3389/fmed.2025.1584032. eCollection 2025.
Acute gastric dilatation (AGD) is a rare but clinically significant condition characterized by abnormal enlargement of the stomach. It can lead to serious complications such as gastric necrosis, perforation, and respiratory failure if not promptly managed. AGD has been associated with mechanical obstructions, binge eating, and systemic conditions like diabetes mellitus. However, AGD induced by excessive consumption of traditional Chinese medicine (TCM) has not been previously reported.
A 40-year-old male with a history of chronic dyspepsia presented to the emergency department with recurrent vomiting. Over the 3 days prior to admission, he self-reported consuming approximately 3.5 liters of TCM liquid (about 1.1-1.3 liters per day). This attempt to alleviate his chronic dyspepsia symptoms failed to show the expected therapeutic effect. The patient denied experiencing headache, dizziness, chest pain, palpitations, abdominal pain, or diarrhea.
Abdominal CT revealed significant gastric distension, and subsequent endoscopy showed pyloric ulcer with stenosis, gastric retention, chronic atrophic gastritis, and a relaxed cardia. Laboratory investigations indicated metabolic alkalosis, electrolyte imbalances, and signs of tissue hypoxia.
The patient was immediately managed with nasogastric tube decompression, anti-infection therapy, gastric mucosal protection, fluid resuscitation, parenteral nutritional support, fasting, and gastrointestinal decompression.
The patient's symptoms and signs notably improved after these interventions. A follow-up CT scan demonstrated improved gastric dilation. At a 4-week follow-up, the patient reported complete resolution of vomiting and resumed normal oral intake. Repeat endoscopy showed healed pyloric ulcers and improved gastric motility. No adverse events (e.g., rehospitalization or medication intolerance) were reported during a 3-month follow-up period.
This case highlights the necessity of including AGD in the differential diagnosis for patients presenting with frequent vomiting after excessive consumption of TCM. It underscores the importance of thorough evaluation to prevent misdiagnosis and severe complications. The case also emphasizes the need for caution when using TCM, especially in patients with organic lesions or pyloric obstruction.
急性胃扩张(AGD)是一种罕见但具有临床意义的病症,其特征为胃异常扩大。若不及时处理,可导致严重并发症,如胃坏死、穿孔和呼吸衰竭。AGD与机械性梗阻、暴饮暴食以及糖尿病等全身性疾病有关。然而,此前尚未有因过量服用中药导致AGD的报道。
一名有慢性消化不良病史的40岁男性因反复呕吐就诊于急诊科。在入院前3天,他自述饮用了约3.5升中药汤剂(每天约1.1 - 1.3升)。此次缓解慢性消化不良症状的尝试未显示出预期的治疗效果。患者否认有头痛、头晕、胸痛、心悸、腹痛或腹泻症状。
腹部CT显示胃显著扩张,随后的内镜检查显示幽门溃疡伴狭窄、胃潴留、慢性萎缩性胃炎以及贲门松弛。实验室检查表明存在代谢性碱中毒、电解质失衡和组织缺氧迹象。
患者立即接受了鼻胃管减压、抗感染治疗、胃黏膜保护、液体复苏、肠外营养支持、禁食和胃肠减压。
经过这些干预措施,患者的症状和体征明显改善。后续CT扫描显示胃扩张有所改善。在4周的随访中,患者报告呕吐完全缓解并恢复了正常经口进食。重复内镜检查显示幽门溃疡愈合且胃动力改善。在3个月的随访期内未报告不良事件(如再次住院或药物不耐受)。
该病例凸显了在过量服用中药后频繁呕吐的患者鉴别诊断中纳入AGD的必要性。强调了全面评估以防止误诊和严重并发症的重要性。该病例还强调了使用中药时需谨慎,尤其是对于有器质性病变或幽门梗阻的患者。