Ismail Izzati Nabilah, Ismail Nor Diyana
Department of Oral and Maxillofacial Surgery and Diagnosis, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.
Department of Respiratory Medicine, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, United Kingdom.
Sleep Sci. 2025 Mar 7;18(2):e223-e235. doi: 10.1055/s-0045-1802650. eCollection 2025 Jun.
Craniofacial phenotyping methods are pivotal in understanding and diagnosing pediatric obstructive sleep apnea (OSA). However, the lack of standardized methods often leads to inconsistencies, hindering the reliability and validity of quantitative analyses in this field. This systematic review aims to evaluate existing craniofacial phenotyping methodologies and their key parameters to propose standardization measures to enhance the reliability and validity of future quantitative analyses on this topic. A comprehensive search of electronic databases was conducted following PRISMA guidelines, resulting in the inclusion of 13 studies. Data extraction focused on the types of phenotyping methods and the parameters or measurements used. Our findings revealed a variation in the phenotyping techniques and a wide array of parameters used across studies, highlighting the need for standardization. The authors proposed a framework of parameters for future evaluation of craniofacial morphologies of pediatric OSA. By standardizing the assessment of these craniofacial morphologies, future research efforts can ensure consistency, facilitating more reliable and valid quantitative analyses in this critical area of study.
颅面表型分析方法对于理解和诊断小儿阻塞性睡眠呼吸暂停（OSA）至关重要。然而，缺乏标准化方法常常导致结果不一致，阻碍了该领域定量分析的可靠性和有效性。本系统评价旨在评估现有的颅面表型分析方法及其关键参数，以提出标准化措施，提高未来关于该主题定量分析的可靠性和有效性。按照PRISMA指南对电子数据库进行了全面检索，纳入了13项研究。数据提取集中在表型分析方法的类型以及所使用的参数或测量值上。我们的研究结果显示，表型分析技术存在差异，且各项研究中使用的参数种类繁多，这凸显了标准化的必要性。作者提出了一个参数框架，用于未来对小儿OSA颅面形态的评估。通过对这些颅面形态评估进行标准化，未来的研究工作可以确保一致性，促进在这一关键研究领域进行更可靠、有效的定量分析。
