de Mezer Mateusz, Dolata Natalia, Markowska Janina, Krzyżaniak Monika, Naskręt-Grochowalska Agnieszka, Żurawski Jakub, Markowska Anna
Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland.
Gynecological Center, Poznan, Poland.
Front Immunol. 2025 Jul 2;16:1571585. doi: 10.3389/fimmu.2025.1571585. eCollection 2025.
Uterine fibroids are benign tumors that occur in a large proportion of women and interfere with the proper functioning of this organ. One of the factors leading to these proliferative changes appears to be the appearance of extracellular matrix (ECM) fibrosis at the site of local inflammatory foci. Due to the potential impact of cytokines in this process, it is interesting to determine their expression levels in fibroids and surrounding tissues, which may contribute to a better understanding of the mechanisms leading to the formation of these tumors. In tissue material from 50 women with uterine fibroids who underwent hysterectomy and 45 women operated on for other reasons (most often prolapse of the reproductive organ), the concentration of inflammatory cytokines IL-1β and IL-6 and the concentration of the transcription nuclear factor NF-κβ were determined. The tissue from the fibroid, the peripheral myometrium, and the unchanged myometrium were examined in women who underwent surgery for reasons other than uterine fibroids. A significant decrease in IL-1β levels was observed in the center of the fibroid compared to both peripheral and control muscle tissue (p=0.001). The concentrations of IL-6 were found to be similar across all three locations examined. The NF-κβ levels were significantly lower in the fibroid and peripheral tissues (p<0.001) compared to the control group. The concentration of IL-1β was found to be significantly and positively correlated with the concentration of NF-κβ in uterine fibroids.
子宫肌瘤是一种常见于大部分女性的良性肿瘤，会干扰子宫的正常功能。导致这些增殖性变化的因素之一似乎是局部炎症病灶部位出现细胞外基质（ECM）纤维化。鉴于细胞因子在这一过程中的潜在影响，确定它们在肌瘤及周围组织中的表达水平很有意义，这可能有助于更好地理解导致这些肿瘤形成的机制。在50例接受子宫切除术的子宫肌瘤女性和45例因其他原因（最常见的是生殖器官脱垂）接受手术的女性的组织材料中，测定了炎性细胞因子IL-1β和IL-6的浓度以及转录核因子NF-κβ的浓度。在因子宫肌瘤以外的原因接受手术的女性中，对肌瘤组织、外周肌层和未改变的肌层进行了检查。与外周和对照肌肉组织相比，肌瘤中心的IL-1β水平显著降低（p=0.001）。在所检查的所有三个部位，IL-6的浓度相似。与对照组相比，肌瘤和外周组织中的NF-κβ水平显著降低（p<0.001）。发现子宫肌瘤中IL-1β的浓度与NF-κβ的浓度显著正相关。
