Ulyanovsk State University, Ulyanovsk, Russia.
Bull Exp Biol Med. 2024 Mar;176(5):607-611. doi: 10.1007/s10517-024-06077-0. Epub 2024 May 11.
The study presents the killer functions of circulating neutrophils: myeloperoxidase activity, the ability to generate ROS, phagocytic activity, receptor status, NETosis, as well as the level of cytokines IL-2, IL-4, IL-6, IL-17A, and IL-18, granulocyte CSF, monocyte chemotactic protein 1, and neutrophil elastase in the serum of patients with uterine myoma and endometrial cancer (FIGO stages I-III). The phagocytic ability of neutrophils in uterine myoma was influenced by serum levels of granulocyte CSF and IL-2 in 54% of the total variance. The degranulation ability of neutrophils in endometrial cancer was determined by circulating IL-18 in 50% of the total variance. In uterine myoma, 66% of the total variance in neutrophil myeloperoxidase activity was explained by a model dependent on blood levels of IL-17A, IL-6, and IL-4. The risk of endometrial cancer increases when elevated levels of monocyte chemotactic protein 1 in circulating neutrophils are associated with reduced ability to capture particles via extracellular traps (96% probability).
髓过氧化物酶活性、产生 ROS 的能力、吞噬活性、受体状态、NETosis 以及血清中细胞因子 IL-2、IL-4、IL-6、IL-17A 和 IL-18、粒细胞集落刺激因子、单核细胞趋化蛋白 1 和中性粒细胞弹性蛋白酶的水平，这些在子宫肌瘤和子宫内膜癌（FIGO 分期 I-III）患者中均有体现。中性粒细胞的吞噬能力受血清粒细胞集落刺激因子和 IL-2 水平影响，占总方差的 54%。中性粒细胞脱颗粒能力由循环 IL-18 决定，占总方差的 50%。在子宫肌瘤中，中性粒细胞髓过氧化物酶活性的总方差的 66%由一个模型解释，该模型取决于血液中 IL-17A、IL-6 和 IL-4 的水平。当循环中性粒细胞中单核细胞趋化蛋白 1 水平升高与通过细胞外陷阱捕获颗粒的能力降低相关时，子宫内膜癌的风险会增加（96%的概率）。
