C57BL小鼠粪便内毒素与粪便微生物群之间的关系。
The relationship between faecal endotoxin and faecal microflora of the C57BL mouse.
作者信息
Rogers M J, Moore R, Cohen J
出版信息
J Hyg (Lond). 1985 Oct;95(2):397-402. doi: 10.1017/s0022172400062823.
Abstract
We studied the effect of oral selective antibiotic decontamination (SD) on the faecal endotoxin content and microflora in individual C57BL mice. Suppression of the coliform count was associated with an initial rise in faecal endotoxin concentration from 0.1 to 3.1 mg/g wet faeces during the first week of SD, which fell to 0.04 mg/g during the second week of treatment. Cessation of SD resulted in an immediate sharp increase in coliform count followed by its decline and gradual recovery to pre-treatment counts. Faecal endotoxin levels followed a parallel course. SD did not effect significantly the counts of lactobacilli, bacteroides and enterococci. It appears that the coliform population is responsible for the overall level of faecal endotoxin, and that during the initial period of SD endotoxin levels are elevated, an effect which may be mediated by antibiotic-enhanced release of endotoxin.
摘要
我们研究了口服选择性抗生素去污（SD）对个体C57BL小鼠粪便内毒素含量和微生物群落的影响。在SD的第一周，大肠菌计数的抑制与粪便内毒素浓度从0.1毫克/克湿粪便初始升高至3.1毫克/克有关，而在治疗的第二周降至0.04毫克/克。停止SD导致大肠菌计数立即急剧增加，随后下降并逐渐恢复到治疗前的计数。粪便内毒素水平呈现平行变化。SD对乳酸杆菌、拟杆菌和肠球菌的计数没有显著影响。看来大肠菌群决定了粪便内毒素的总体水平，并且在SD的初始阶段内毒素水平升高，这种效应可能是由抗生素增强的内毒素释放介导的。
相似文献
1
The relationship between faecal endotoxin and faecal microflora of the C57BL mouse.C57BL小鼠粪便内毒素与粪便微生物群之间的关系。
J Hyg (Lond). 1985 Oct;95(2):397-402. doi: 10.1017/s0022172400062823.
2
Kinetics of endotoxin release by gram-negative bacteria in the intestinal tract of mice during oral administration of bacitracin and during in vitro growth.在小鼠肠道内口服杆菌肽期间以及体外生长期间革兰氏阴性菌释放内毒素的动力学
Scand J Infect Dis. 1988;20(2):213-9. doi: 10.3109/00365548809032440.
3
Oral administration of antibiotics and intestinal flora associated endotoxin in mice.小鼠口服抗生素与肠道菌群相关内毒素
Scand J Infect Dis. 1986;18(1):55-63. doi: 10.3109/00365548609032307.
4
[Effect of antibiotics on the intestinal tract microflora of guinea pigs].
Antibiotiki. 1975 Oct;20(10):902-3.
5
Faecal endotoxin and activity of the gut-associated lymphoid tissue in patients with malignant (B-cell) lymphoma.
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Jul;259(4):520-30. doi: 10.1016/s0176-6724(85)80084-5.
6
The effect of selective decontamination of the digestive tract with the addition of systemic cefotaxime on the aerobic faecal flora of mice.添加全身性头孢噻肟对小鼠需氧粪便菌群进行消化道选择性去污的效果。
Epidemiol Infect. 1987 Jun;98(3):385-95. doi: 10.1017/s0950268800062154.
7
Effect of dalbavancin on the normal intestinal microflora.达巴万星对正常肠道微生物群的影响。
J Antimicrob Chemother. 2006 Sep;58(3):627-31. doi: 10.1093/jac/dkl281. Epub 2006 Jul 12.
8
Influence of the destabilisation of the maternal digestive microflora on that of the newborn rat.
Biol Neonate. 1993;63(4):236-45. doi: 10.1159/000243937.
9
Biological inactivation by faeces of antimicrobial drugs applicable in selective decontamination of the digestive tract.适用于消化道选择性去污的抗菌药物被粪便生物灭活。
J Antimicrob Chemother. 1984 Dec;14(6):605-12. doi: 10.1093/jac/14.6.605.
10
Reversible binding of polymyxin B and neomycin to the solid part of faeces.
J Antimicrob Chemother. 1986 Mar;17(3):333-9. doi: 10.1093/jac/17.3.333.
引用本文的文献
1
Magnitude of Septic Shock and its Associated Factors Among Critically Ill COVID-19 Patients at Addis Ababa COVID-19 Care Centers, Ethiopia.埃塞俄比亚亚的斯亚贝巴新冠病毒疾病护理中心危重症新冠病毒疾病患者的感染性休克严重程度及其相关因素
SAGE Open Nurs. 2024 Oct 3;10:23779608241281865. doi: 10.1177/23779608241281865. eCollection 2024 Jan-Dec.
2
Competitive Analysis of Rumen and Hindgut Microbiota Composition and Fermentation Function in Diarrheic and Non-Diarrheic Postpartum Dairy Cows.腹泻和非腹泻产后奶牛瘤胃与后肠微生物群组成及发酵功能的比较分析
Microorganisms. 2023 Dec 22;12(1):23. doi: 10.3390/microorganisms12010023.
3
Insight Into Polysaccharides From C. A. Meyer in Improving Intestinal Inflammation: Modulating Intestinal Microbiota and Autophagy.浅析 C. A. Meyer 多糖改善肠道炎症的作用机制：调节肠道微生物群和自噬。
Front Immunol. 2021 Jul 20;12:683911. doi: 10.3389/fimmu.2021.683911. eCollection 2021.
4
Antibiotics, Inflammation, and Preterm Labor: A Missed Conclusion.抗生素、炎症与早产：一个被忽视的结论。
J Inflamm Res. 2020 May 25;13:245-254. doi: 10.2147/JIR.S248382. eCollection 2020.
5
Possible Cause of Inflammatory Storm and Septic Shock in Patients Diagnosed with (COVID-19).（COVID-19）患者中炎症风暴和感染性休克的可能病因。
Arch Med Res. 2020 May;51(4):347-348. doi: 10.1016/j.arcmed.2020.03.015. Epub 2020 Apr 4.
6
The effect of selective decontamination of the digestive tract with the addition of systemic cefotaxime on the aerobic faecal flora of mice.添加全身性头孢噻肟对小鼠需氧粪便菌群进行消化道选择性去污的效果。
Epidemiol Infect. 1987 Jun;98(3):385-95. doi: 10.1017/s0950268800062154.
7
Investigation of the immune status of mice during and following selective decontamination of the digestive tract.消化道选择性去污期间及之后小鼠免疫状态的研究
Epidemiol Infect. 1989 Oct;103(2):323-32. doi: 10.1017/s0950268800030685.
本文引用的文献
1
The fecal flora of various strains of mice. Its bearing on their susceptibility to endotoxin.不同品系小鼠的粪便菌群。其与小鼠对内毒素易感性的关系。
J Exp Med. 1962 Jun 1;115(6):1149-60. doi: 10.1084/jem.115.6.1149.
2
On the absorption of bacterial endotoxin from the gastro-intestinal tract of the normal and shocked animal.关于正常动物和休克动物胃肠道对细菌内毒素的吸收
J Exp Med. 1960 Nov 1;112(5):783-92. doi: 10.1084/jem.112.5.783.
3
Bacterial endotoxins: chemical structure, biological activity and role in septicaemia.细菌内毒素：化学结构、生物活性及在败血症中的作用
Scand J Infect Dis Suppl. 1982;31:8-21.
4
The endotoxin-liberating effect of antibiotics on meningococci in vitro.抗生素在体外对脑膜炎球菌的内毒素释放作用。
Acta Pathol Microbiol Scand B. 1980 Aug;88(4):231-6. doi: 10.1111/j.1699-0463.1980.tb02633.x.
5
Observations on the measurement and evaluation of endotoxemia by a quantitative limulus lysate microassay.利用定量鲎试剂微量分析法对内毒素血症进行测量与评估的观察
J Infect Dis. 1984 Dec;150(6):916-24. doi: 10.1093/infdis/150.6.916.
6
Kinetics of endotoxin release during antibiotic therapy for experimental gram-negative bacterial sepsis.实验性革兰氏阴性菌败血症抗生素治疗期间内毒素释放的动力学
J Infect Dis. 1984 Sep;150(3):380-8. doi: 10.1093/infdis/150.3.380.
7
The persistent absence of Enterobacteriaceae from the intestinal flora of mice following antibiotic treatment.抗生素治疗后小鼠肠道菌群中肠杆菌科细菌持续缺失。
J Infect Dis. 1968 Feb;118(1):32-8. doi: 10.1093/infdis/118.1.32.
8
The mouse intestinal microflora with emphasis on the strict anaerobes.以严格厌氧菌为重点的小鼠肠道微生物群。
J Exp Med. 1971 Feb 1;133(2):339-52. doi: 10.1084/jem.133.2.339.
9
Transport and storage of faeces for bacteriological examination.用于细菌学检查的粪便运输与储存。
J Appl Bacteriol. 1971 Jun;34(2):477-83. doi: 10.1111/j.1365-2672.1971.tb02307.x.
10
Some effects of Escherichia coli endotoxin on the graft-versus-host reaction in mice.大肠杆菌内毒素对小鼠移植物抗宿主反应的某些影响。
Transplantation. 1972 Oct;14(4):432-7.
Zotero 插件