Vasco Gabriela, Cruz Cecilia, Peñaherrera Paterson, Tipán Katherine, Pila Sandy, Guzmán Karol, Cabascango Marisol, Logacho Katherine, Jácome Patricio
Universidad Central del Ecuador Facultad de Ciencias Médicas Quito Ecuador Facultad de Ciencias Médicas, Universidad Central del Ecuador, Quito, Ecuador.
Unidad de Genética y Molecular Instituto Ecuatoriano de Seguridad Social Hospital de Especialidades Carlos Andrade Marín Quito Ecuador Unidad de Genética y Molecular, Hospital de Especialidades Carlos Andrade Marín, Instituto Ecuatoriano de Seguridad Social, Quito, Ecuador.
Rev Bras Ginecol Obstet. 2025 Jul 15;47. doi: 10.61622/rbgo/2025rbgo31. eCollection 2025.
Successful measures to address the increasing prevalence of sexually transmitted infections (STIs) require practical and accessible education and detection programs.
The ability to detect and may be hindered by a lack of adherence to proper cervical sampling. To address this, we compared the sensitivity and specificity of self-obtained samplings, such as self-collection and first-catch urine samples, to cervical samples taken by a practitioner using the nucleic acid amplification test (NAAT) cobas 4800 for and in 244 women attending gynecological services in Quito, Ecuador. Regardless of sampling method, only 12 patients tested positive for (4.9% prevalence, 95% CI 2.8 to 8.4%), and no samples tested positive for .
The analysis revealed that self-collection was 100% sensitive (95% CI 66.4% to 100.0%) and 100% specific (95% CI 98.25%-100%), and first-catch urine was 90% sensitive (95% CI 55.5% to 99.8%), and 99% specific (95% CI 96.5% to 99.9%) compared to cervical brushing for the detection of . No symptoms were associated with a positive result, highlighting the need for testing even in asymptomatic patients. Furthermore, having a stable intimate relationship in the past year was associated with a negative result for (χ 14.01, < 0.001).
This study demonstrates the feasibility and reliability of self-collection and first-catch urine samples as alternative methods for detecting and has practical implications for improving STI detection and management programs.
应对性传播感染（STIs）患病率上升的成功措施需要切实可行且易于获得的教育和检测项目。
由于缺乏对正确宫颈采样的依从性，检测能力可能会受到阻碍。为解决这一问题，我们在厄瓜多尔基多接受妇科服务的244名女性中，使用核酸扩增检测（NAAT）cobas 4800，比较了自我采集样本（如自我收集和首次晨尿样本）与从业者采集的宫颈样本对[某种疾病]的敏感性和特异性。无论采样方法如何，只有12名患者检测出[某种疾病]呈阳性（患病率4.9%，95%置信区间2.8%至8.4%），且没有样本检测出[另一种疾病]呈阳性。
分析显示，与宫颈刷检相比，自我收集对[某种疾病]检测的敏感性为100%（95%置信区间66.4%至100.0%），特异性为100%（95%置信区间98.25% - 100%），首次晨尿的敏感性为90%（95%置信区间55.5%至99.8%），特异性为99%（95%置信区间96.5%至99.9%）。没有症状与[某种疾病]检测阳性结果相关，这突出表明即使是无症状患者也需要进行检测。此外，过去一年有稳定的亲密关系与[某种疾病]检测结果为阴性相关（χ² = 14.01，P < 0.001）。
本研究证明了自我收集和首次晨尿样本作为检测[某种疾病]替代方法的可行性和可靠性，对改进性传播感染检测和管理项目具有实际意义。
