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非小细胞肺癌的纵隔分期:有哪些新进展?

Mediastinal staging of nonsmall cell lung cancer: what's new?

作者信息

Bradley Claire, Novoa Nuria, Riva Laura, Lampaki Sophia, Ricciardi Sara, Rovanias Michael, Chaabouni Malek, Turner Richard, Zachariou Antonia, Hardavella Georgia, Navani Neal

机构信息

Belfast City Hospital Health and Social Services Trust, Respiratory Medicine, Belfast, UK.

Puerta de Hierro University Hospital of Majadahonda, Madrid, Spain.

出版信息

Breathe (Sheff). 2025 Jul 15;21(3):230191. doi: 10.1183/20734735.0191-2023. eCollection 2025 Jul.

DOI:10.1183/20734735.0191-2023
PMID:40673063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12260911/
Abstract

In this review, we explore the importance of accurate mediastinal staging in nonsmall cell lung cancer, which directly impacts management options and prognosis. We outline the various means of staging, including radiological and interventional techniques, with a focus on the advantages and limitations of the different approaches. The review also identifies ways in which mediastinal staging has changed over time, particularly with the advent of effective endoscopic nodal sampling, and how emerging research and developments may lead to further adjustments in clinical practice. The role of multidisciplinary decision making, particularly in complex cases, remains integral to the process of mediastinal staging in lung cancer.

摘要

在本综述中,我们探讨了非小细胞肺癌准确纵隔分期的重要性,其直接影响治疗方案的选择和预后。我们概述了各种分期方法,包括放射学和介入技术,重点介绍了不同方法的优缺点。该综述还确定了纵隔分期随时间的变化方式,特别是有效内镜下淋巴结采样技术的出现,以及新出现的研究和进展如何可能导致临床实践的进一步调整。多学科决策的作用,特别是在复杂病例中,仍然是肺癌纵隔分期过程中不可或缺的一部分。

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本文引用的文献

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BMJ Open Respir Res. 2024 Dec 12;11(1):e002617. doi: 10.1136/bmjresp-2024-002617.
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Liquid biopsy in cancer current: status, challenges and future prospects.癌症液体活检的现状、挑战与未来前景
Signal Transduct Target Ther. 2024 Dec 2;9(1):336. doi: 10.1038/s41392-024-02021-w.
3
Neoadjuvant and Adjuvant Treatments for Early Stage Resectable NSCLC: Consensus Recommendations From the International Association for the Study of Lung Cancer.早期可切除 NSCLC 的新辅助和辅助治疗:国际肺癌研究协会的共识建议。
J Thorac Oncol. 2024 Oct;19(10):1373-1414. doi: 10.1016/j.jtho.2024.06.010. Epub 2024 Jun 18.
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Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.系统内镜分期纵隔引导局部晚期非小细胞肺癌放疗计划(SEISMIC):一项国际多中心单臂临床试验。
Lancet Respir Med. 2024 Jun;12(6):467-475. doi: 10.1016/S2213-2600(24)00010-9. Epub 2024 Mar 12.
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