Imai S, Hosoi T, Kawai Y, Kanesawa N, Kanda H, Suzuki T, Murata K
J Cardiogr. 1985 Mar;15(1):147-53.
Left ventricular (LV) diastolic properties in dilated cardiomyopathy (DCM), transmural myocardial infarction (TMI), and hypertrophic cardiomyopathy (HCM) were evaluated. Radionuclide angiography and M-mode echocardiography were performed for 11 cases of DCM, 40 cases of TMI, 21 cases of HCM, and nine normal control subjects. In DCM, the peak filling rate (PFR) and filling fraction (FF) were significantly reduced, but the time to the peak filling rate (TPFR) was not prolonged. In TMI, both the PFR and FF were significantly reduced. Moreover, the TPFR was significantly prolonged in TMI as compared to DCM. Although depression of the PFR in HCM was not apparent, prolongation of the TPFR in HCM was marked. In DCM, there was good correlation between the PFR and left ventricular ejection fraction (EF) (r = 0.71, p less than 0.03). In TMI, there was a good correlation between the TPFR and the standard deviation of the LV phase angle histogram (SDP), indicating LV asynergy (r = 0.589, p less than 0.005). In HCM, both the FF and PFR correlated inversely with the LV wall thickness (r = -0.74, p less than 0.008; r = -0.581, p less than 0.03, respectively). These results indicate that various factors affect LV diastolic properties in heart disease, and that radionuclide angiography is a valuable technique for evaluating LV diastolic function.
对扩张型心肌病（DCM）、透壁性心肌梗死（TMI）和肥厚型心肌病（HCM）的左心室（LV）舒张特性进行了评估。对11例DCM、40例TMI、21例HCM患者以及9名正常对照者进行了放射性核素血管造影和M型超声心动图检查。在DCM中，峰值充盈率（PFR）和充盈分数（FF）显著降低，但达到峰值充盈率的时间（TPFR）未延长。在TMI中，PFR和FF均显著降低。此外，与DCM相比，TMI中的TPFR显著延长。虽然HCM中PFR的降低不明显，但HCM中TPFR的延长很显著。在DCM中，PFR与左心室射血分数（EF）之间存在良好的相关性（r = 0.71，p < 0.03）。在TMI中，TPFR与左心室相位角直方图的标准差（SDP）之间存在良好的相关性，表明左心室运动不协调（r = 0.589，p < 0.005）。在HCM中，FF和PFR均与左心室壁厚度呈负相关（分别为r = -0.74，p < 0.008；r = -0.581，p < 0.03）。这些结果表明，多种因素影响心脏病中的左心室舒张特性，并且放射性核素血管造影是评估左心室舒张功能的一种有价值的技术。
