Matsumoto M, Yasui K, Shimazu T, Maeda T, Nakajima S, Matsuyama T, Fujiwara M, Fukushima M, Hamanaka Y, Inoue M
J Cardiogr. 1985 Mar;15(1):23-9.
For the echocardiographic assessment of intramyocardial blood flow distribution by intravenous contrast echocardiographic technique, we measured the echo intensity of a point (phi 6 mm) in the interventricular septum using a lightmeter in end-diastole before and after the intravenous injection of various dosages of ether or hydrogen peroxide in one open-chest and four closed-chest dogs. Before the injection of contrast media, the echo intensity of the myocardium varied within a range of 6.1 +/- 4.6% After the injection of ether or hydrogen peroxide, the echo intensity of the myocardium increased. After the occlusion of the left anterior descending artery, echo enhancement of the left ventricular wall occurred, except for the left ventricular anterior wall and the interventricular septum. Between dosage (x) and % increase (y), relations of y = 127x - 3, in ether and y = 1.17x + 1.11, in hydrogen peroxide were observed. We found that the intravenous injection of at least 0.2 ml ether or 15 mg hydrogen peroxide was necessary to achieve effective echo enhancement of the myocardium in dogs.
为了通过静脉注射造影剂超声心动图技术对心肌内血流分布进行超声心动图评估，我们在一只开胸和四只闭胸犬中，于静脉注射不同剂量的乙醚或过氧化氢前后，使用光度计在舒张末期测量了室间隔中一个点（直径6毫米）的回声强度。在注射造影剂之前，心肌的回声强度在6.1±4.6%的范围内变化。注射乙醚或过氧化氢后，心肌的回声强度增加。在左前降支动脉闭塞后，除左心室前壁和室间隔外，左心室壁出现回声增强。在剂量（x）和增加百分比（y）之间，观察到在乙醚中y = 127x - 3以及在过氧化氢中y = 1.17x + 1.11的关系。我们发现，静脉注射至少0.2毫升乙醚或15毫克过氧化氢对于在犬中实现心肌有效的回声增强是必要的。
