Yasui K, Matsumoto M, Shimazu T, Maeda T, Nakajima S, Fukushima M, Hori M, Inoue M, Abe H, Satoh H, Minamino T
J Cardiogr. 1982 Dec;12(4):895-903.
To assess intramyocardial blood flow distribution by the contrast echocardiographic technique, we studied the effect of intracoronary injections of contrast agents on the echo intensity of the myocardium. As fundamental experiments, we made injections of ICG, urografin, artificial blood (FC-43) and microsphere into the coronary artery in open chest dogs and observed the changes in echo density of the myocardium. Bolus injection of 10 ml ICG into the coronary artery produced little change in the myocardial echo intensity, but bolus injection of 10 ml urografin, FC-43 and microsphere into the left circumflex coronary artery (LCX) and left anterior descending coronary artery (LAD) immediately increased the echo intensity of the left ventricular posterior wall (LVPW) and interventricular septum (IVS), respectively. Enhanced echo areas correlated well with the regions perfused by LCX and LAD, respectively. Clinically, we recorded two-dimensional echocardiograms during coronary arteriography (CAG) in 10 patients. In six of the 10 patients, the echo intensity of IVS increased during left CAG and in four of eight patients the echo intensity of LVPW increased during right CAG. Contrast echomyocardiography, contrast enhanced echocardiography of the myocardium, proved a useful technique for the evaluation of intramyocardial blood flow.
为了通过对比超声心动图技术评估心肌内血流分布，我们研究了冠状动脉内注射造影剂对心肌回声强度的影响。作为基础实验，我们在开胸犬的冠状动脉内注射了吲哚菁绿（ICG）、泛影葡胺、人造血液（FC - 43）和微球，并观察心肌回声密度的变化。向冠状动脉内一次性推注10 ml ICG对心肌回声强度几乎没有影响，但向左旋支冠状动脉（LCX）和左前降支冠状动脉（LAD）内一次性推注10 ml泛影葡胺、FC - 43和微球后，分别立即增加了左心室后壁（LVPW）和室间隔（IVS）的回声强度。增强的回声区域分别与LCX和LAD灌注的区域密切相关。临床上，我们对10例患者在冠状动脉造影（CAG）期间记录了二维超声心动图。在10例患者中的6例中，左冠状动脉造影期间室间隔的回声强度增加，在8例患者中的4例中，右冠状动脉造影期间左心室后壁的回声强度增加。心肌对比超声心动图，即心肌对比增强超声心动图，被证明是评估心肌内血流的一种有用技术。
